| 血清超敏C反应蛋白水平对阿奇霉素治疗儿童支原体肺炎疗效的影响 |
| 投稿时间：2016-11-23 修订日期：2017-01-01 点此下载全文 |
| 引用本文：王磊,魏彬.血清超敏C反应蛋白水平对阿奇霉素治疗儿童支原体肺炎疗效的影响[J].医学研究杂志,2017,46(9):181-184 |
| DOI：
10.11969/j.issn.1673-548X.2017.09.047 |
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| 中文摘要:目的 探讨血清超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）水平对阿奇霉素治疗儿童支原体肺炎疗效的影响。方法 选取2013年6月~2016年6月间崇州市妇幼保健院诊治的68例支原体肺炎患儿为研究对象，所有患儿均予以每天10mg/kg阿奇霉素，观察治疗期间患儿临床症状、胸部X线片变化及不良反应发生情况，并利用乳胶免疫比浊法测定hs-CRP水平。结果 所有患儿血清hs-CRP测定平均值19.06±3.01mg/L，测定中位数为12.92mg/L，均>10mg/L的正常上限值；将患儿以hs-CRP中位数值分为高hs-CRP组和低hs-CRP组；两组患儿在年龄、性别、病程和体温方面比较，差异均无统计学意义（P>0.05）；低hs-CRP组患者的总体有效率为94.12%，显著高于高hs-CRP组的76.47%，差异有统计学意义（χ2=4.221，P=0.040）；高hs-CRP组患儿的咳嗽、喘息持续时间和病灶吸收时间均长于低hs-CRP组（P<0.05）；但两组患儿在退热时间、住院时间、不良反应发生率比较，差异均无统计学意义（P>0.05）。结论 hs-CRP在儿童支原体肺炎中发挥重要作用，且阿奇霉素对偏低水平hs-CRP支原体肺炎患儿的临床疗效更优。 |
| 中文关键词:超敏C反应蛋白 阿奇霉素 儿童支原体肺炎 |
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| Effect of Serum High Sensitive C Reactive Protein Level on the Curative Effect of Azithromycin in Treatment of Mycoplasma Pneumonia in Children |
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| Abstract:Objective To investigate the effect of serum high sensitive C reactive protein (hs-CRP) level on the curative effect of azithromycin in treatment of mycoplasma pneumonia in children. Methods The 68 cases of children with mycoplasma pneumonia in Maternal and Child Health Care Hospital of Chongzhou were selected as the research objects from June 2013 to June 2016. All the children were treated with 10mg/kg azithromycin daily. The clinical symptoms, chest X-ray changes and adverse reactions of children during treatment were observed and the level of hs-CRP was determined by latex immunoassay. Results The mean value of serum hs-CRP was (19.06±3.01), and the median of serum hs-CRP was 12.92mg/L, which were higher than the normal upper limit value of 10mg/L. Children were divided into high hs-CRP group and low hs-CRP group by the median value of hs-CRP. There were no significant differences in the age, sex, course of disease and body temperature between the two groups (P>0.05). The overall effective rate of low hs-CRP group was 94.12%, which was significantly higher than that of high hs-CRP group at 76.47% (χ2=4.221, P=0.040). The duration of cough, wheezing and lesion absorption time in high hs-CRP group were longer than those in the low hs-CRP group (P<0.05). But no significant difference was observed in time of fever, hospitalization time, the incidence of adverse reactions between two groups (P>0.05). Conclusion hs-CRP plays an important role in children's mycoplasma pneumonia, and the clinical effect of azithromycin is much better on the patients with low level of hs-CRP. |
| keywords:High sensitive C reactive protein Azithromycin Mycoplasma pneumonia in children |
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