| 421例住院新生儿血清25羟维生素D水平的临床观察 |
| 投稿时间：2017-01-22 修订日期：2017-02-11 点此下载全文 |
| 引用本文：邹敏书,宋秋菊,徐洪涛,尹太勇,张么成,余健,聂国明.421例住院新生儿血清25羟维生素D水平的临床观察[J].医学研究杂志,2017,46(10):40-43,52 |
| DOI：
10.11969/j.issn.1673-548X.2017.10.011 |
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| 基金项目:国家自然科学基金资助项目（81373179） |
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| 中文摘要:目的 观察住院新生儿25羟维生素D[25（OH） D]水平，并分析其与临床指标之间的相关性。方法 随机选取421例住院新生儿，ELISA方法检测血清25（OH） D的水平，并用Pearson相关分析探讨25（OH） D水平与临床指标如肝肾功能、电解质及心肌酶谱等的相关性。结果 421例新生儿血清25（OH） D水平为15.31±8.36 ng/m1。早产儿（71例）、ABO溶血症（24例）、新生儿高胆红素血症（215例）、新生儿窒息（14例）、新生儿肺炎（22例）、新生儿湿肺（25例）血清25（OH） D水平分别是13.93±7.60、14.48±8.68、14.84±7.41、16.58±6.56、17.42±9.43、18.71±8.67ng/ml。与早产儿、ABO溶血症、高胆红素血症组相比，正常足月新生儿及新生儿湿肺组血清VitD水平明显升高（P < 0.05）。不同性别、不同出生体重新生儿血清25（OH） D水平无显著性差异。足月儿血清25（OH） D水平较早产儿明显升高。夏秋季出生的新生儿血清25（OH） D水平较春冬季出生的新生儿明显升高，差异有统计学意义（P < 0.05）。秋季出生的新生儿总蛋白、球蛋白较春冬季出生的新生儿明显降低，而白蛋白/球蛋白较春冬季出生的新生儿明显升高，血钙在秋季出生的新生儿中最高。新生儿血清25（OH） D水平缺乏或不足比率较高，占73.1%。新生儿血清25（OH） D水平与母体25（OH） D水平高度相关（r=0.365，P=0.000）；与白蛋白、血钙呈正相关（r分别为0.123、0.221，P=0.009、0.000）；与体重、总胆红素呈负相关（r=-0.103、-0.148，P=0.036、0.002）；与胎龄、肾功能、心肌酶、白细胞计数、C反应蛋白无相关性。结论 不同疾病、胎龄、季节出生的新生儿血清25（OH） D水平不同，住院新生儿血清25（OH） D水平缺乏或不足非常普遍，血清25（OH） D水平与母体VitD水平、白蛋白、血钙、体重、总胆红素有一定的相关性。 |
| 中文关键词:维生素D 新生儿 住院 肝功能 心肌酶 |
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| Clinical Observation on Serum 25-hydroxy-vitamin D Levels in 421 Cases of Hospitalized Newborns |
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| Abstract:Objective To investigate the baseline levels of 25-hydroxy-vitamin D[25(OH)D] in 421 cases of hospitalized newborns, and analysis the correlation of 25(OH)D with other clinical indicators. Methods Totally 421 cases in hospitalized newborns were randomly selected. 25(OH)D levels were detected by ELISA method, and the Pearson correlation analysis of 25(OH)D level and clinical indicators such as liver and renal function, electrolytes and myocardial enzyme was performed. Results Serum 25(OH)D levels in 421 cases of hospitalized newborns was 15.31±8.36ng/ml. Serum 25 (OH)D levels in newborns with preterm infants (71 cases), ABO hemolytic disease (24 cases), neonatal high bilirubin blood disease (215 cases), neonatal asphyxia (14 cases),neonatal pneumonia (22 cases), neonatal wet lung (25 cases) were 13.97±7.60, 14.48±8.68, 14.84±7.41, 16.58±6.56, 17.42±9.43, 18.71±8.67ng/ml, respectively. Serum 25(OH)D levels in groups of neonatal wet lung and premature were higher than those of preterm infants, ABO hemolytic disease, neonatal high bilirubin blood disease (P < 0.05). There was no significant difference in serum VitD levels between different gender and different birth weight newborns. Serum 25(OH)D levels in term infant were higher than those of premature. Serum 25 (OH)D levels in newborns who were born in summer and autumn were obviously higher than those in spring and winter, respectively, and there was significant difference. Total protein, globulin were significantly lower, however albumin/globulin was obviously higher in newborns who were borm in autumn than those in spring and winter, and blood calcium was the highest in autumn. The percentage of serum 25(OH)D deficiency and insufficiency in newborns accounted for 73.1%. The serum levels of 25(OH)D were highly correlated with maternal levels of 25(OH)D (r=0.365, P=0.000), positively correlated with albumin and Ca (r=0.123, 0.221, P=0.009, 0.000), respectively, and negatively correlated with weight and total bilirubin (r=-0.103, -0.148, P=0.036, 0.002), respectively. Levels of 25(OH)D and gestational age, renal function, myocardial enzyme, white blood cell count, C-reactive protein had no relevance, respectively. Conclusion Serum 25(OH)D level is different in different disease, gestational age, season in neowborns. The prevalence of Vitamin D deficiency and insufficient is high in hospitalized neowborns. The level of serum 25(OH)D have relevance with maternal VitD levels, albumin, Ca, weight and total bilirubin. |
| keywords:Vitamin D Newborns In the hospital Liver function Myocardial enzyme |
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