| 静脉钙负荷甲状旁腺功能抑制实验的临床应用及安全性评价 |
| 投稿时间：2016-12-08 修订日期：2016-12-22 点此下载全文 |
| 引用本文：王新玲,衣巴地古丽·库吐鲁克,张竞,王静,玛依努·玉素甫,努荣古丽·买买提,张洁,吴岚,郭艳英.静脉钙负荷甲状旁腺功能抑制实验的临床应用及安全性评价[J].医学研究杂志,2017,46(10):92-95 |
| DOI：
10.11969/j.issn.1673-548X.2017.10.024 |
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| 基金项目:新疆维吾尔自治区科技基础条件平台建设项目（PT1601） |
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| 中文摘要:目的 探讨静脉钙负荷甲状旁腺功能抑制试验鉴别原发性、继发性甲状旁腺功能亢进症的临床应用及安全性评价。方法 对疑似甲状旁腺功能亢进患者进行静脉钙负荷甲状旁腺功能抑制试验，共收集37例，以73%作为诊断切点，并参考甲状旁腺B超检查及病理结果，根据最后诊断分为原发性甲状旁腺功能亢进症（PHPT）、继发性甲状旁腺功能亢进症（SHPT）两组，其中PHPT组13例，SHPT组24例，比较两组间一般资料、生化指标、PTH抑制率（PTH-IR）等。结果 PHPT组血钙、碱性磷酸酶（ALP）明显高于SHPT组，PHPT组血磷、PTH-IR、PTH-IR/Δ血钙明显低于SHPT组；120minPTH-IR分别为PHPT （28.01±5.5）%，SHPT （79.1±4.2）%，两组间比较差异有统计学意义。结论 静脉钙负荷甲状旁腺功能抑制试验对于鉴别PHPT及SHPT有一定的敏感度和特异性，且临床应用无不良反应，是一种行之有效的功能试验。 |
| 中文关键词:甲状旁腺功能亢进症 静脉钙负荷甲状旁腺功能抑制试验 鉴别 |
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| Clinical Value and Safety Evaluation of Intravenous Calcium Suppression Test |
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| Abstract:Objective To investigate the clinical value and safety evaluation of intravenous calcium suppression test in the identification of primary and secondary hyperparathyroidism(HPT). Methods A total of 37 patients with hyperparathyroidism were divided into two groups according to 73% as the cut-off value, parathyroid ultrasonography and pathological reports. Baseline data,biochemical indicator and the inhibition rate of PTH (PTH-IR) were compared. Results In primary HPT (PHPT) group,serum calcium and ALP were significantly higher than secondary HPT(SHPT) group.Serum phosphorus,PTH-IR[PTH-IR=(PTH level at 0min-maximal PTH level)/PTH level at 0min],PTH-IR/ΔCa(maximal Ca level-Ca level at 0min) were significantly smaller than SHPT group.There was significant difference in the PTH-IR among PHPT and SHPT. Conclusion Intravenous calcium suppression test is a kind of effective functional test and it has higher sensitivity and specificity in identification of PHPT and SHPT,and no adverse reaction in clinical application. |
| keywords:Hyperparathyroidism Intravenous calcium suppression test Differentiation |
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