| 卡泊三醇治疗寻常性银屑病的临床疗效观察 |
| 投稿时间：2017-01-20 修订日期：2017-02-19 点此下载全文 |
| 引用本文：吴志华,王慧珍.卡泊三醇治疗寻常性银屑病的临床疗效观察[J].医学研究杂志,2017,46(10):190-193,59 |
| DOI：
10.11969/j.issn.1673-548X.2017.10.047 |
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| 中文摘要:目的 探讨卡泊三醇治疗寻常性银屑病的临床疗效。方法 选取2013年1月~2016年6月于中国人民解放军第一八四医院皮肤科收治的306例稳定期寻常性银屑病，随机分成对照组与试验组，每组153例。均予消银胶囊、维生素C、叶酸以及窄谱中波紫外线等基础治疗，对照组再予复方丙酸氯倍他索软膏外敷，试验组在上述基础上再予卡泊三醇软膏外敷。检测血清炎性细胞因子、T淋巴细胞亚群及皮肤屏障功能指标，评估皮损严重程度（PASI）与皮肤病学生活质量指数（DLQI），比较治疗效果。结果 与治疗前比较，两组干扰素γ（IFN-γ）、白介素-2（IL-2）、白介素-17（IL-17）及白介素-18（IL-18）降低（P < 0.01），CD3+、CD4+及CD4+/CD8+升高（P < 0.01），CD8+降低（P < 0.01），皮脂含量、角质层含水量升高（P < 0.01），pH值降低（P < 0.01），PASI评分、DLQI评分降低（P < 0.01）；与对照组比较，试验组IFN-γ、IL-2、IL-17及IL-18较低（P < 0.01），CD3+、CD4+及CD4+/CD8+较高（P < 0.01），CD8+较低（P < 0.01），皮脂含量、角质层含水量较高（P < 0.01），pH值较低（P < 0.01），PASI评分、DLQI评分较低（P < 0.01），治疗有效率较高（P < 0.01）。结论 卡泊三醇治疗寻常性银屑病效果显著，值得临床推广。 |
| 中文关键词:寻常性银屑病 卡泊三醇 临床疗效 |
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| Observation on the Curative Effect of Calcipotriol in the Treatment of Psoriasis Vulgaris |
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| Abstract:Objective To investigate the effect of calcipotriol in the treatment of psoriasis vulgaris. Methods 306 patients with stable psoriasis vulgaris were randomly divided into control group (n=153) and experimental group (n=153).Patients received in 2 groups received Vitamin C, folic acid and narrow-band UVB treatment. The control group was treated with clobetasol propionate ointment, those and in the experimental group was treated with topical ointment of calcipotriol. Scores of PASI and dermatological quality of life (DLQI) were measured, and the therapeutic effect,the serum levels of inflammatory cytokines, T lymphocyte subpopulations and skin barrier function were compared between the two groups. Results Compared with before treatment, levels of IFN-γ, IL-2, IL-17 and IL-18 in the two groups decreased (P<0.01), levels of CD3+, CD4+ and CD4+/CD8+ increased (P<0.01), levels of CD8+ decreased (P<0.01), levels of sebum content, water content of cuticle increased (P<0.01), levels of PH value decreased (P<0.01), PASI score, DLQI score decreased (P<0.01). Compared with the control group, the levels of IFN-γ, IL-2, IL-17 and IL-18 were lower (P<0.01), levels of CD3+, CD4+ and CD4+/CD8+ were higher (P<0.01), levels of CD8+ was lower(P<0.01), sebum content, water content of cuticle were higher (P<0.01), PH value was lower(P<0.01), PASI score and DLQI score were lower(P<0.01). Conclusion The efficacy of calcipotriol in treating psoriasis vulgaris is significant, worth of clinical promotion. |
| keywords:Psoriasis vulgaris Calcipotriol Curative effect |
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