索利那新与曲司氯铵治疗膀胱过度活动症疗效与安全性的比较
投稿时间:2017-03-06  修订日期:2017-03-09  点此下载全文
引用本文:李文坚,朱喜山,戴晓农.索利那新与曲司氯铵治疗膀胱过度活动症疗效与安全性的比较[J].医学研究杂志,2017,46(11):145-148
DOI: 10.11969/j.issn.1673-548X.2017.11.035
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作者单位E-mail
李文坚 213001 常州市第三人民医院 bolite@163.com 
朱喜山 213001 常州市第三人民医院  
戴晓农 213001 常州市第三人民医院  
中文摘要:目的 比较索利那新与曲司氯铵治疗膀胱过度活动症(OAB)的疗效和安全性。方法 选取2015年3月~2016年5月于笔者医院门诊确诊为膀胱过度活动症的患者共79例。随机分为两组,A组40例,给予索利那新5毫克/次,1次/天,疗程12周;B组39例,给予曲司氯铵20毫克/次,2次/天,疗程12周。对两组所有患者分别在0、4、12周进行OAB症状评分(OABSS)并评估服用药物期间出现的不良反应以及停药率。结果 两组在0、4、12周OABSS得分分别为9.3±2.6和10.2±1.9,2.5±1.3和2.7±1.4,1.4±0.5和1.3±0.6;两组在0、4、12周得分差异无统计学意义(P=0.084,P=0.512和P=0.423)。由于不良反应导致的停药率两组分别为0(0%)和5(12.8%)。两组内0、4、12周OABSS得分比较差异均有统计学意义(P=0.000)。结论 两种药物各时段OABSS得分差异无统计学意义,提示临床疗效相似,但曲司氯铵因不良反应导致停药率更高。
中文关键词:膀胱过度活动症  索利那新  曲司氯铵
 
Comparison of Solifenacin and Trospium in Treatment of Overactive Bladder
Abstract:Objective To compare the use of solifenacin and trospium in treatment of overactive bladder (OAB).Methods This prospective study was conducted on patients diagnosed with OAB who presenting to the Department of urology, Changzhou No.3 People's Hospital between March 2015 and May 2016. Patients were randomized into 2 groups. Group A (n=40) received 5 mg solifenacin once daily, while Group B (n=39) received 20 mg trospium twice daily. All the patients' OAB symptom scores (OABSS) in weeks 0, 4, and 12 were recorded. In addition, side effects of the drugs were evaluated.Results Average OABSS was determined as:9.3±2.6 (Group A) and 10.2±1.9 (Group B) at week 0; 2.5±1.3 (Group A) and 2.7±1.4 (Group B) at week 4; and 1.4±0.5 (Group A) and 1.3 ±0.6 (Group B) at week 12. In addition, no statistically significant difference was found between the scores (P=0.084, P=0.512 and P=0.423). The discontinuation rate of medication due to its side effects was 0 (0%) for Group A, and 5 (12.8%) for Group B. Intragroup changes in the scores 0 weeks-4 weeks, 0 weeks-12 weeks and 4 weeks-12 weeks values was statistically significant in both groups (P=0.000).Conclusion No significant difference was found between the OABSS of these 2 drugs. However, discontinuation of drugs due to side effects was more frequent in trospium.
keywords:Overactive bladder  Solifenacin  Trospium
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