| 65例男性干燥综合征患者的临床特点分析 |
| 投稿时间：2017-05-24 修订日期：2017-06-19 点此下载全文 |
| 引用本文：宣磊,王景,董振华.65例男性干燥综合征患者的临床特点分析[J].医学研究杂志,2017,46(12):137-140 |
| DOI：
10.11969/j.issn.1673-548X.2017.12.034 |
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| 中文摘要:目的 总结男性原发性干燥综合征（pSS）临床发病特点及系统受累情况，提高对男性pSS的关注。方法 病史采集，收集患者临床资料，分析男性pSS疾病特点。结果 935例pSS中男性65例、女性870例，男、女性别比例为0.7：10。男性确诊经历时间中位数为10个月，平均病程中位数为36个月，均较女性时间短（P<0.05）。65例男性患者Schirmer试验异常率12.3%，低于女性异常率50.6%，差异有统计学意义（P<0.05）。依据唇腺活检病理结果阳性而确诊的男性占40%，女性占25.4%，差异有统计学意义（P<0.05）。男性发生淋巴结肿大者占16.9%，女性占5.2%，差异有统计学意义（P<0.05）；54.48%女性、36.92%男性发生系统受累；3%的男性出现1个系统以上的多系统受累，女性发生率为10.8%，两方面比较，差异有统计学意义（P<0.05）。血液系统损害患者中，105例（12.1%）女性出现血小板计数减少，65例男性均未发生血小板计数减小，差异有统计学意义（P<0.05）。其他常见系统损害发生率与女性比较差异无统计学意义（P>0.05）。结论 男性pSS发病比例明显低于女性，口干眼干程度较女性轻，确诊困难；发生消化、呼吸、泌尿和神经系统受累比例与女性比较，差异无统计学意义，临床需关注。 |
| 中文关键词:干燥综合征 性别差异 对比研究 |
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| Clinical Characteristics of 65 Male Patients with Sjögren's Syndrome |
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| Abstract:Objective To analyze the different clinical features and system lesions of female and male primary Sjögren's syndrome (pSS) patients and to attract more attention to male pSS patients' pathogenic features.Methods Clinical information of pSS patients was gathered and physicochemical tests were conducted. The clinical features of female and male patients were summarized and analyzed.Results 935 pSS cases were collected,among which 65 cases were male. The male-female ratio was 0.7:10. The man's median duration of diagnosis was 10 months, with a median duration of 36 months, compared with women's time (P<0.05).There were significant statistical differences between both the dry mouth and dry eyes occurrence rate of female and male patients(P<0.05). In ophthalmic Schirmer tests, 440 female patients and 8 male presented abnormal results (P<0.05). For labial gland biopsy,the positive rate of male patients was much higher than that of the female (P<0.05). The incidence of lymphadenectasis of male patients was 16.9%, which was higher than that of female patients (5.2%),presenting statistical significance (P<0.05). As regards pSS system lesions, 54.48% of the female presenting presented system lesions, while this rate for male patients was only 36.92%; the rate of multiple system lesions for female and male patients was 10.8% and 3% (P<0.05).The incidence of lymphadenectasis of male patients was higher than that of female patients (P<0.05). As regards pSS system lesions,the incidence of multiple system involvement was low(P<0.05).Conclusion The incidence of male pSS is significantly lower than that of female. Dry mouth dryness is lower than that of female, and there is no difference in digestive, respiratory, urinary and nervous system involvement. |
| keywords:Sjögren's syndrome Gender difference Comparative study |
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