| 秋水仙碱对痛风性关节炎患者肿瘤标志物的影响 |
| 投稿时间：2016-10-22 修订日期：2016-10-22 点此下载全文 |
| 引用本文：章丽和,金珍木,李素蘋.秋水仙碱对痛风性关节炎患者肿瘤标志物的影响[J].医学研究杂志,2017,46(12):154-156,164 |
| DOI：
10.11969/j.issn.1673-548X.2017.12.038 |
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| 中文摘要:目的 探讨不同剂量及疗程的秋水仙碱片对痛风性关节炎患者肿瘤标志物的影响及动态变化。方法 回顾分析急性痛风性关节炎患者102例，根据入院前是否曾服用秋水仙碱片，将其分为观察组1（服药组）和观察组2（未服药组）。观察组2又细分为观察组2A和观察组2B两个亚组，观察组2A及观察组1的患者入院当天给予0.5mg每天两次的秋水仙碱和相应的NSAID治疗，观察组2B的患者入院次日开始服用相同剂量的秋水仙碱片。同时纳入31例同期在院治疗的非痛风性关节炎患者作为对照组。所有患者于入院后次日检测红细胞沉降率、C反应蛋白、血肌酐、血尿酸、CA724、AFP、CEA、CA125、CA153、CA199等指标，分析不同观察组之间的差异及影响因素。1周后复测CA724水平，并追踪随访部分患者，于停用秋水仙碱1个月后再次评估CA724水平。结果 与对照组比较，服用秋水仙碱的痛风性关节炎患者CA724明显升高，两者比较差异有统计学意义（P<0.05）。观察组2A第1天的CA724值明显高于观察组2B，两组间比较差异有统计学意义（P<0.05），服用极小剂量秋水仙碱即可导致CA724升高，且其升高水平与使用疗程及总剂量呈正相关。停用药物后复查CA724值基本可降至正常范围。结论 服用秋水仙碱片可显著影响CA724的血清水平，并随药物剂量及疗程增加而逐渐上升，在停药后该指标可恢复正常，可避免临床上误诊及过度医疗，有一定的指导意义。 |
| 中文关键词:糖类抗原724 秋水仙碱片 痛风性关节炎 肿瘤标志物 |
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| Effect of Colchicine on Tumor Markers in Patients with Gouty Arthritis |
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| Abstract:Objective To explore the influence of different doses and courses of colchicine on tumor markers in patients with gouty arthritis.Methods Totally 102 patients with acute gouty arthritis were divided into group 1(had taken colchicine before in hospital)and group 2(hadn't taken colchicine before in hospital).Group 2 was divided into two subgroups, group 2A and group 2B. We also included 31 cases of non-gouty arthritis patients in the same period in the hospital as control group. Group 2A and group 1 were given 0.5 mg bid of colchicine and corresponding NSAID on the day admitted to hospital. Group 2B were given the same dose of colchicine the next day. Blood sedimentation, c-reactive protein, serum creatinine, blood uric acid, CA724, AFP, CEA, CA125, CA153 and CA199 were detected in all patients on the next day admitted to hospital. Then we analyzed the differences and influencing factors among the groups. Retest CA724 1 week later, and follow-up parts of patients, reevaluate CA724 again after stopping using colchicine.Results Compared with the control group, CA724 significantly elevated in patients who took colchicine, and the difference was statistically significant.CA724 level of day 1 in group 2A was obviously higher than that of group 2B, and the difference between the two groups was statistically significant. It showed that very low dose colchicine can also result in higher CA724, and the level was closely relative to total dose and using course. After stopping drug, CA724 value can drop to normal range.Conclusion Colchicine can significantly affect the level of serum CA724, which gradually rise with the increase of drug dose and course. It can be back to normal after drug withdrawal. The discovery can avoid the clinical misdiagnosis and excessive medical treatment, It has certain guiding significance. |
| keywords:Carbohydrate antigen 724(CA724) Colchicine Gouty arthritis Tumor markers |
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