| 奥氮平联合西酞普兰治疗慢性紧张型头痛临床研究 |
| 投稿时间：2017-04-11 修订日期：2017-04-30 点此下载全文 |
| 引用本文：杜衍君,邢舒平,都晓帆,张爱娟.奥氮平联合西酞普兰治疗慢性紧张型头痛临床研究[J].医学研究杂志,2018,47(1):148-152 |
| DOI：
10.11969/j.issn.1673-548X.2018.01.037 |
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| 中文摘要:目的 探讨小剂量奥氮平联合西酞普兰治疗慢性紧张型头痛的临床疗效。方法 将入选的符合慢性紧张型头痛诊断标准的300例患者，随机平均分为治疗组（奥氮平+西酞普兰组）和对照组1（阿米替林组）、对照组2（西酞普兰组），并进行随机单盲对照研究，测评3组患者治疗前后（治疗前，治疗后4、8、12周）的疼痛程度，发作次数，发作时间及汉密顿焦虑量表（HAMA）、汉密顿抑郁量表（HAMD）、蒙特利尔认知评估量表（MOCA）、匹茨堡睡眠质量指数量表（PSQI）、TESS不良反应量表等指标。结果 治疗组与对照组相比较疼痛程度明显缓解，发作天数明显减少，持续时间明显缩短，HAMA、HAMD、PSQI量表评分显著下降（P<0.05），MOCA量表评分有所升高（P<0.05）。治疗组与对照组治疗效果均随着时间变化而增加（P<0.05），治疗组随时间变化的幅度明显大于对照组（P<0.05），TESS评分相对较低（P<0.05）。结论 小剂量奥氮平联合西酞普兰在治疗慢性紧张型头痛中疗效显著，起效快，对患者焦虑、抑郁情绪及睡眠、认知方面有明显的改善，具有较高的安全性，值得在临床中推广使用。 |
| 中文关键词:西酞普兰 奥氮平 慢性紧张型头痛 |
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| Olanzapine Combined with Citalopram in the Treatment of Chronic Tension-headache |
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| Abstract:Objective To investigate the clinical efficacy of low-dose olanzapine combined with citalopram in the treatment of chronic tension headache. Methods A total of 300 patients with chronic tension headache were enrolled in the study. They were randomly divided into three groups:the treatment group(olanzapine combined with citalopram group) and the control group 1 (amitriptyline group), the control group 2(citalopram group), and the scores of pain, seizure frequency, attack time Hamilton Anxiety Scale (HAMA),Hamilton Depression Scale (HAMD), Montreal Cognitive Assessment Scale (MOCA), Pittsburgh Sleep Quality Index (PSQI), TESS and other indicators were measured and compared with those of the three group before and after the treatment (before treatment, 4 weeks, 8 weeks and 12 weeks after treatment). Results Compared with the control group, the pain of the treatment group was significantly alleviated, the number of episodes decreased significantly, the duration was significantly shortened, HAMA, HAMD, PSQI(P<0.05), and the MOCA score was significantly higher (P<0.05). The therapeutic effect of the treatment group and the control group all increased with the time (P<0.05), and the time of the treatment group was significantly larger than that of the control group (P<0.05). TESS score was lower (P<0.05). Conclusion Low-dose olanzapine combined with citalopram is effective in the treatment of chronic tension-type headache. It is an effective treatment for patients with anxiety, depression, sleep and cognitive improvement and it is low incidence of adverse reaction.So it is worthy of clinic application. |
| keywords:Citalopram Olanzapine Chronic tension-type headache |
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