| 早期肠内营养混悬液营养支持联合生长抑素对ICU重症胰腺炎患者血清PCT、PA、TF、AMY水平变化及预后的影响 |
| 投稿时间：2017-05-12 修订日期：2017-05-24 点此下载全文 |
| 引用本文：王超.早期肠内营养混悬液营养支持联合生长抑素对ICU重症胰腺炎患者血清PCT、PA、TF、AMY水平变化及预后的影响[J].医学研究杂志,2018,47(2):79-82,91 |
| DOI：
10.11969/j.issn.1673-548X.2018.02.019 |
| 摘要点击次数: 1009 |
| 全文下载次数: 774 |
|
| 基金项目:北京市科学技术委员会基金资助项目（D151100004912001） |
|
| 中文摘要:目的 探究早期肠内营养混悬液营养支持联合生长抑素对ICU重症胰腺炎患者血清降钙素原（PCT）、前白蛋白（PA）、转铁蛋白（TF）、淀粉酶（AMY）水平变化及预后的影响。方法 选取2014年7月~2016年11月首都医科大学附属北京同仁医院ICU重症胰腺炎患者66例，依据治疗方案分为对照组（n=33）与治疗组（n=33）。对照组予以早期肠外营养支持+生长抑素治疗，治疗组予以早期肠内营养混悬液营养支持+生长抑素治疗。统计两组并发症发生情况，并对比两组治疗前后预后相关评分（APACHEⅡ、SOFA及改良Marshall评分）、血清PCT、PA、TF、AMY水平及血清相关炎性因子[白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、肿瘤坏死因子-α（TNF-α）]水平。结果 两组治疗前APACHEⅡ、SOFA及改良Marshall评分差异均无统计学意义（P>0.05）；治疗后与对照组相比，治疗组APACHEⅡ、SOFA及改良Marshall评分均较低，差异有统计学意义（P<0.05）；两组治疗前血清PCT、PA、TF、AMY水平差异均无统计学意义（P>0.05）；治疗后与对照组相比，治疗组血清PCT、AMY水平均较低，血清PA、TF水平较高，差异有统计学意义（P<0.05）；两组治疗前血清TNF-α、IL-6及IL-10水平比较差异均无统计学意义（P>0.05）；治疗后与对照组相比，治疗组血清TNF-α、IL-6水平均较低，血清IL-10水平较高，差异有统计学意义（P<0.05）；治疗组并发症发生率15.15%（5/33）低于对照组42.42%（14/33），差异有统计学意义（P<0.05）。结论 早期肠内营养混悬液营养支持联合生长抑素治疗ICU重症胰腺炎患者，可有效提高血清PA、TF及IL-10水平，降低PCT、AMY、TNF-α、IL-6水平，改善预后且安全性较高。 |
| 中文关键词:早期肠内营养混悬液营养支持 生长抑素 ICU重症胰腺炎 血清细胞因子 预后 |
| |
| Changes of Serum PCT, PA, TF, AMY Levels and Prognosis in ICU Patients with Severe Acute Pancreatitis by Nutritional Support of Early Enteral Nutrition Suspension Combined with Somatostatin |
|
|
| Abstract:Objective To investigate the effect of early enteral nutrition suspension nutritional support combined with somatostatin on serum procalcitonin (PCT), prealbumin (PA), transferrin (TF) and amylase (AMY) in ICU patients with severe acute pancreatitis.Methods From July 2014-November 2016, 66 cases of ICU severe pancreatitis in Beijing Tongren Hospital were divided into control group and treatment group according to treatment plan, 33 cases each group. The control group was given early parenteral nutrition support + somatostatin treatment, The treatment group was given early enteral nutrition suspension nutrition support + somatostatin treatment. Complications of the tw groups were compared, prognostic score (APACHEⅡ, SOFA and modified Marshall scores), serum PCT, PA, TF, AMY levels and serum-related inflammatory factors[interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α)] before and after treatment were compared.Results There was no significant difference in APACHEⅡ, SOFA and modified Marshall scores between the two groups before treatment (P>0.05). Compared with the control group after treatment, the APACHEⅡ, SOFA and modified Marshall scores of the treatment group were lower than those of the control group (P<0.05). There was no significant difference in serum PCT, PA, TF and AMY between the two groups before treatment (P>0.05). Compared with the control group after treatment, the levels of serum PCT and AMY in the treatment group were lower than those in the control group, and the levels of serum PA and TF were higher (P<0.05). There was no significant difference in serum TNF-α, IL-6 and IL-10 levels between the two groups before treatment (P>0.05). Compared with the control group after treatment, the levels of serum TNF-α and IL-6 in the treatment group were lower than those in the control group, and the serum IL-10 level was higher (P<0.05). The incidence of complications in the treatment group was 15.15% (5/33) lower than that in the control group (42.42%, 14/33), the difference was statistically significant (P<0.05).Conclusion Early stage enteral nutrition suspension nutrition support combined with somatostatin in the treatment of ICU severe pancreatitis patients can effectively improve serum levels of PA, TF and IL-10, reduce PCT, AMY, TNF-α, IL-6 levels, improve the prognosis, and its security is high. |
| keywords:Early enteral nutrition suspension nutritional support Somatostatin ICU severe pancreatitis Serum cytokines Prognosis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
