乳腺癌组织中lncRNA MALAT1的表达及临床意义
投稿时间:2017-05-11  修订日期:2017-05-27  点此下载全文
引用本文:李子博,周江,周琳,杨芳慧,李敏.乳腺癌组织中lncRNA MALAT1的表达及临床意义[J].医学研究杂志,2018,47(3):79-81
DOI: 10.11969/j.issn.1673-548X.2018.03.020
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作者单位E-mail
李子博 410219 长沙医学院医学检验系 lzb3039@126.com 
周江 410219 长沙医学院医学检验系  
周琳 410219 长沙医学院医学检验系  
杨芳慧 410219 长沙医学院医学检验系  
李敏 410219 长沙医学院医学检验系  
基金项目:湖南省科技厅科技计划项目(2014FJ3062)
中文摘要:目的 探讨长链非编码RNA MALAT1在乳腺癌组织中的表达及临床意义。方法 采用实时荧光定量聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)方法检测64例乳腺癌患者癌组织标本及其对应的癌旁组织标本中MALAT1的表达情况,分析其与乳腺癌的临床病理特征关系以及诊断价值。结果 MALAT1在乳腺癌组织中的表达明显高于癌旁组织(P<0.05),且癌组织中MALAT1的表达水平与ER、PR表达情况以及淋巴结转移明显相关明显相关(P<0.05);ROC曲线分析发现AUC为0.706。结论 组织中高表达的MALAT1可作为乳腺癌诊断的一个潜在的新型生物学标志物。
中文关键词:长链非编码RNA  MALAT1  乳腺癌
 
Expression and Clinical Significance of Long Non-coding RNA MALAT1 in Breast Cancer
Abstract:Objective To investigate the expression and clinical significance of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1(MALAT1) in breast cancer. Methods MALAT1 levels were measured in breast cancer tissue samples and corresponding adjacent tissues from 64 breast cancer patients using quantitative real-time PCR. The correlation between MALAT1 levels and clinical pathological characteristics of breast cancer was analyzed.A receiver operating characteristic (ROC) curve was constructed to determine the diagnostic value of MALAT1. Results The expression levels of MALAT1 in cancer tissues were significantly higher than those in adjacent tissues (P<0.05). The expression levels of MALAT1 in breast cancer patients correlated with expression of ER, PR and lymph node metastasis (P<0.05); the area under the ROC curve was 0.706. Conclusion Plasma lncRNAMALAT1 may be involved in carcinogenesis and prove as a potential biomarker for the diagnosis of breast cancer.
keywords:Long non-coding RNA  MALAT1  Breast cancer
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