超重及肥胖与急性高原反应关系的Meta分析
投稿时间:2017-07-27  修订日期:2017-08-29  点此下载全文
引用本文:方露,徐成丽.超重及肥胖与急性高原反应关系的Meta分析[J].医学研究杂志,2018,47(4):28-31
DOI: 10.11969/j.issn.1673-548X.2018.04.008
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作者单位E-mail
方露 100000 中国医学科学院基础医学研究所/北京协和医学院基础学院  
徐成丽 100000 中国医学科学院基础医学研究所/北京协和医学院基础学院 xuchengli@pumc.edu.cn 
基金项目:中国医学科学院中央级公益性科研院所基本科研业务费环境与健康研究中心基金资助项目(2016ZX310181)
中文摘要:目的 探讨超重及肥胖与急性高原反应(AMS)发生的相关性。方法 检索万方、维普、知网、PubMed、Embase、Springer、Google Scholar、Cochrane等数据库。以急性高原病、急性高原反应、低氧通气反应、超重、肥胖、体质量指数、BMI、队列研究、病例对照研究、横断面研究、观察性研究作为关键词收集2007~2016年探讨超重及肥胖与AMS相关性的研究,由两名评价者独立对其进行归纳整理。运用RevMan 5.3软件进行统计分析。结果 最终纳入相关文献6篇,纳入研究对象6323例;异质性检验发现纳入研究存在异质性(I2=93%,P<0.01),采用随机效应模型进行合并。超重及肥胖组AMS的发生风险明显增加,合并OR值为2.39(95%CI:1.21~4.70)。敏感度分析表明结果较稳定,Egger's检验结果P>0.05,纳入研究无发表偏倚。结论 超重及肥胖为AMS发生的危险因素。
中文关键词:急性高原反应  超重  肥胖  Meta分析
 
Meta Analysis of the Relationship between Overweight, Obesity and Acute Mountain Sickness
Abstract:Objective To investigate the relationship between overweight, obesity and acute mountain sickness(AMS). Methods We searched the WanFang, CNKI, VIP, PubMed, Embase, Springer, Google Scholar, Cochrane databases. AMS, acute high altitude disease, acute high altitude disease (AHAD), hypoxic ventilatory response (HVR), obese, obesity, BMI, Body Mass Index, cohort study, case-control study, cross-sectional study and observational study were used to search literatures which studied association between overweight, obesity and AMS during 2007-2016. Literatures were then evaluated by two evaluators. RevMan 5.3 software was utilized for statistical analysis. Results Six articles with 6323 cases were included in the study. The heterogeneity test result revealed that included studies were statistically heterogeneous (I2=93%, P<0.01), therefore, the random effect model was used to analyze. Obesity and overweight significantly increased the occurrence of AMS with an OR of 2.39 (95% CI:1.21-4.70). Egger's test indicated that there was no publication bias (P>0.05). Conclusion Overweight and obesity can be used as predictors of occurrence for AMS.
keywords:Acute mountain sickness  Overweight  Obesity  Meta analysis
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