| 血清补体C3与代谢综合征的关系研究 |
| 投稿时间：2017-06-29 修订日期：2017-07-19 点此下载全文 |
| 引用本文：刘莎莎,陈丹,张静,黄玉婷,阿丽米拉·赛依提江,佴志慧,高颖.血清补体C3与代谢综合征的关系研究[J].医学研究杂志,2018,47(4):69-72 |
| DOI：
10.11969/j.issn.1673-548X.2018.04.018 |
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| 基金项目:新疆维吾尔科技援建项目（2016E02074） |
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| 中文摘要:目的 分析血清补体C3水平与代谢综合征的关系。方法 观察组选取MS患者65例，对照组选取无MS的正常人群65例作为研究对象，采用免疫比浊法测定血浆补体C3水平，比较两组人群中糖脂代谢指标，并分析补体C3水平与代谢综合征各组分的相关性，应用ROC曲线评价补体C3诊断MS的价值。结果 MS组中补体C3水平高于无MS组（P<0.05），随着MS各组分从0增加到4时，补体C3水平均逐渐升高，补体C3水平从Q1到Q4组，MS及其各组分的检出率均有升高趋势且危险性升高（P<0.05），利用ROC诊断MS的补体C3的最佳截位点是0.89g/L，敏感度为65.6%，特异性为80.6%，ROC曲线下面积0.775，95% CI：0.694~0.856（P<0.05）。结论 补体C3与代谢综合征及其组分密切相关，可能是MS发生的相关因素，并对MS发病有一定的预测价值。 |
| 中文关键词:补体C3 代谢综合征 ROC曲线 |
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| Correlative Research of the Serum Complement C3 Level with Metabolic Syndrome |
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| Abstract:Objective To investigate the correlation between the serum complement C3 level with metabolic syndrome. Methods Observational group was composed of 65 patients with metabolic syndrome, and another 65 normal people as the control group.The serum complement C3 were measured by immunoturbidimetry. The parameters related to glucolipid metabolism were compared among two groups, and assess the association of the complement C3 level with metabolic syndrome and its components, The value of C3 in diagnosis of MS was assessed according to the receiver operating characteristic(ROC) curve. Results The level of complement C3 was significantly higher in MS patients than in non-MS patients(P<0.05).Complement C3 rose gradually along with the increased number one to four of MS components.The incidence and risk of MS and its abnormal components were significantly higher in the Q4 group with higher level of complement C3 when compared to the group with lower level (P<0.05).The optimal complement C3 cutoff point for the diagnosis of MS according to the ROC curve was 0.89g/L with a sensitivity of 65.6% and a specificity of 80.6%.The area under the ROC curve was0.775 (95% CI:0.694-0.856). Conclusion The serum complement C3 level was closely related with metabolic syndrome and its components.It is a factor for MS and a certain value for the prediction of MS. |
| keywords:Serum complement C3 Metabolic syndrome ROC curve |
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