| 急性缺血性脑卒中发病早期血清脑红蛋白和HIF-1α水平变化及意义 |
| 投稿时间：2017-06-15 修订日期：2017-08-21 点此下载全文 |
| 引用本文：蒋瑞冲,王琦伟,徐敉,许春立,许文杰.急性缺血性脑卒中发病早期血清脑红蛋白和HIF-1α水平变化及意义[J].医学研究杂志,2018,47(4):125-129,133 |
| DOI：
10.11969/j.issn.1673-548X.2018.04.031 |
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| 中文摘要:目的 检测急性缺血性脑卒中患者早期血清NGB和HIF-1水平，并评估两者与患者神经损伤程度及预后的关系。方法 研究纳入2011年6月~2015年6月期间的60例急性缺血性脑卒中患者及60例健康对照组志愿者。于发病后24、48、72、96h血清NGB及HIF-1α水平进行检测，并与健康对照组志愿者进行比较。同时分析急性缺血性脑卒中患者血清NGB及HIF-1α水平峰值与脑梗死体积、NIHSS评分及预后的关系。结果 AIS患者发病后24h可见血清NGB水平（16.43±1.09μg/ml）和HIF-1α水平（233.90±26.30μg/ml）显著高于对照组（NGB：10.18±1.01μg/ml，HIF-1α：121.00±35.5μg/ml），之后持续升高，NGB水平于发病后72h达峰（20.50±1.83μg/ml），HIF-1α水平于发病后48h达峰（411.67±50.46μg/ml）。AIS患者血清NGB及HIF-1α峰值与脑梗体积及NIHSS评分均呈正相关。预后良好组血清NGB峰值及HIF-1α峰值（NGB：23.68±1.51μg/ml，HIF-1α：387.63±38.23μg/ml）均显著低于预后不良组（NGB：26.29±1.09μg/ml，HIF-1α：463.55±30.64μg/ml）。ROC曲线分析显示，血清NGB和HIF-1α峰值均可较好的预测预后不良事件。结论 NGB和HIF-1α血清水平均与AIS患者梗死体积和神经损伤程度呈正相关，且可较好的预测AIS患者预后情况。提示NGB和HIF-1α血清水平具有作为分子标志物，评价缺血性脑卒中患者神经功能损伤严重程度及预后的潜在可能性。 |
| 中文关键词:急性缺血性脑卒中 脑红蛋白 缺氧诱导因子1 |
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| Changes and Clinical Significance in Serum Neuroglobin and HIF-1α during the Early-phase of Acute Ischemic Stroke |
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| Abstract:Objective To investigate the level of serum neuroglobin and HIF-1α during the early-phase of acute ischemic stroke, and evaluate their relationship to stroke severity and prognosis. Methods The study included 60 AIS patients and 60 heathy controls during June, 2011 to June 2015 in our hospital.The serum NGB and HIF-1α levels of AIS patients were examined at 24, 48, 72, 96 hours after stroke and compared with health controls.The relationship of serum NGB and HIF-1α peak level to infarct size, NIHSS score and prognosis were analyzed. Results The level of serum NGB (16.43±1.09μg/ml) and HIF-1α (233.90±26.30μg/ml) 24 hours after stroke were significantly higher than those of health controls (NGB:10.18±1.01μg/ml,HIF-1α:121.00±35.5μg/ml).Serum NGB (20.50±1.83μg/ml) and HIF-1α (411.67±50.46μg/ml) reached the peak concentrations at 72 hours and 48 hours after stroke, respectively.Peak concentration of NGB and HIF-1α were positively correlated with infarct size and NIHSS score.Peak concentration of NGB and HIF-1α of good prognosis group (NGB:23.68±1.51μg/ml,HIF-1α:387.63±38.23μg/ml) were significantly lower than those of poor prognosis group (NGB:26.29±1.09μg/ml,HIF-1α:463.55±30.64μg/ml).ROC curve analysis suggested that the serum NGB and HIF-1α had significantly predictive power for poor outcome. Conclusion Serum NGB and HIF-1α concentration had positively correlations with the nerve injury severity and good predictive power for poor outcome in AIS patients, which indicated that serum NGB and HIF-1α concentration may be used as molecular markers to evaluate the nerve injury severity and prognosis in AIS patients. |
| keywords:Acute ischemic stroke Neuroglobin HIF-1 |
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