| 非小细胞肺癌组织中HIF-1α、EGFR、IGF-1的表达及临床意义 |
| 投稿时间：2017-06-25 修订日期：2017-07-03 点此下载全文 |
| 引用本文：刘勇进,俞列群,叶帆.非小细胞肺癌组织中HIF-1α、EGFR、IGF-1的表达及临床意义[J].医学研究杂志,2018,47(5):78-82 |
| DOI：
10.11969/j.issn.1673-548X.2018.05.019 |
| 摘要点击次数: 829 |
| 全文下载次数: 720 |
|
| 基金项目:浙江省自然科学基金资助项目（LY14H130018） |
|
| 中文摘要:目的 探讨非小细胞肺癌（NSCLC）组织中缺氧诱导因子-1α（HIF-1α）、胰岛素样生长因子（IGF-1）、表皮生长因子受体（EGFR）的表达水平及临床意义。方法 采用蛋白免疫印迹法检测NSCLC组织及癌旁非肿瘤组织中HIF-1α、EGFR、IGF-1的表达情况，并与临床病理特征及预后做相关分析。结果 NSCLC组织中HIF-1α、IGF-1、EGFR的蛋白表达均显著高于癌旁非肿瘤组织（P<0.05）。HIF-1α与IGF-1表达在鳞癌和腺癌中的差异均无统计学意义（P>0.05），EGFR在鳞癌中的表达显著高于腺癌（P<0.05）。低分化癌组织中HIF-1α、IGF-1、EGFR的表达水平均显著高于中、高分化癌组织（P<0.05），Ⅰ、Ⅱ期肿瘤组织中HIF-1α、IGF-1、EGFR的表达水平显著低于Ⅲ、Ⅳ期肿瘤组织（P<0.05），且有淋巴结转移组织中的HIF-1α、IGF-1、EGFR表达水平显著高于无淋巴结转移组织（P<0.05）。HIF-1α与EGFR表达水平呈显著正相关（r2=0.301，P<0.05），且与IGF-1表达水平呈显著正相关（r2=0.611，P<0.05）。HIF-1α、EGFR及IGF-1的表达水平与患者预后无明显相关性（P>0.05）。结论 HIF-1、EGFR、IGF-1在NSCLC组织中表达均显著增加，HIF-1与EGFR及EGF-1均呈正相关，且HIF-1α、IGF-1、EGFR的表达水平与分化程度、TNM分期、淋巴结转移密切相关，且EGFR与病理类型密切相关，在NSCLC的发生、发展过程中起重要作用。 |
| 中文关键词:非小细胞肺癌 缺氧诱导因子-1α 表皮生长因子受体 胰岛素样生长因子-1 |
| |
| Expression of HIF-1α, EGFR and IGF-1 in Non-small Cell Lung Cancer and Its Clinical Significance |
|
|
| Abstract:Objective To investigate the expression of hypoxia-inducible factor-1α (HIF-1α), insulin-like growth factor (IGF-1) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) and their clinical significance.Methods The expression of HIF-1α, EGFR and IGF-1 in NSCLC tissues and adjacent non-tumor tissues were detected by western blot, and the correlation with clinicopathological features and prognosis were analyzed.Results The expression of HIF-1α, IGF-1 and EGFR in NSCLC tissues were significantly higher than that in non-tumorous tissues. There were no significant difference in the expression of HIF-1α and IGF-1 in squamous cell carcinoma and adenocarcinoma(P>0.05). The expression of EGFR in squamous cell carcinoma was significantly higher than that in adenocarcinoma(P<0.05). The expression of HIF-1α, IGF-1 and EGFR in low differentiated carcinoma were significantly higher than those in medium and high differentiated carcinoma tissues,and the expression of HIF-1α, IGF-1 and EGFR in stage Ⅰ and Ⅱ tumor tissues were significantly lower than those in stage Ⅲ and Ⅳ tumor tissues(P<0.05). The expression of HIF-1α, IGF-1 and EGFR with lymph node metastasis were significantly higher than that without lymph node metastasis in tumor tissues. There was a significant positive correlation between the expression of HIF-1α and EGFR(r2=0.301,P<0.05), and the expression of HIF-1α was positively correlated with the expression of IGF-1 (r2=0.611,P<0.05). The expression of HIF-1α, EGFR and IGF-1 had no significant correlation with the prognosis (P>0.05).Conclusion HIF-1, EGFR and IGF-1 were significantly increased in NSCLC tissues, and HIF-1 was positively correlated with EGFR and EGF-1, and the expression of HIF-1α, IGF-1 and EGFR are closely related to the degree of differentiation, TNM staging and lymph node metastasis, and EGFR is closely related to pathological type. They play an important role in the development and progression of NSCLC. |
| keywords:Non-small cell lung cancer HIF-1α EGFR IGF-1 |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
