| SLC39A6基因表达与膀胱癌的关系研究 |
| 投稿时间：2017-08-16 修订日期：2017-09-01 点此下载全文 |
| 引用本文：苏娟.SLC39A6基因表达与膀胱癌的关系研究[J].医学研究杂志,2018,47(6):35-38 |
| DOI：
10.11969/j.issn.1673-548X.2018.06.010 |
| 摘要点击次数: 836 |
| 全文下载次数: 664 |
|
| 基金项目:湖北省自然科学基金资助项目（2012FFA096） |
|
| 中文摘要:目的 探讨SLC39A6基因在膀胱癌中的表达情况及其临床意义。方法 采用荧光定量PCR检测54例膀胱癌患者手术切除的病理标本中膀胱癌组织和相应的癌旁正常组织中SLC39A6基因的表达情况，并分析膀胱癌组织中SLC39A6基因的表达量变化与肿瘤的分级和临床病理分期之间的关系。结果 SLC39A6基因在癌旁正常组织中呈低表达，相对表达量为0.353±0.057；在膀胱癌组织中高表达，相对表达量为0.592±0.069，两组SLC39A6基因相对表达量比较差异有统计学意义（P<0.05）。在膀胱癌组织中，SLC39A6基因相对表达量与癌组织的临床分期、分化程度呈正相关（P=0.000）。结论 人膀胱癌组织中SLC39A6基因的表达水平较正常膀胱组织增高，并可能促进了膀胱癌细胞的侵袭和转移。 |
| 中文关键词:SLC39A6 膀胱癌 分期 |
| |
| Expression of SLC39A6 in Hnman Bladder Cancer |
|
|
| Abstract:Objective To investigate the expression of SLC39A6 in hnman bladder cancer and its clinical significance. Methods Real-time quantitative PCR was used to detect the expression of SLC39A6 in para-carcinoma tissue and bladder cancer tissue, and all the tissues were derived from the pathological specimens of 54 cases of bladder cancer patients. Besides, we will analyse the correlation between the expression of SLC39A6 and the histological grade and clinical pathologic staging of bladder cancer. Results The expression level of SLC39A6 in para-carcinoma tissue and bladder cancer tissue were respectively 0.353±0.057 and 0.592±0.069. The result of comparison between two groups shows that the expression level of SLC39A6 in bladder cancer tissue is significantly higher than that in para-carcinoma tissue, so there is a significant difference between two groups(P<0.05). In addition, the expression level of of SLC39A6 in bladder cancer tissue were significantly increased with the increasing of histological grades and clinical pathologic staging(P=0.000). Conclusion The expression of SLC39A6 in human bladder cancer tissue is up-regulated compared with normal human bladder tissue, and it may promote the invasiveness and metastasis of bladder cancer. |
| keywords:SLC39A6 Bladder cancer Clinical pathologic staging |
| 查看全文 查看/发表评论 下载PDF阅读器 |
