| 微波消融治疗非小细胞肺癌临床疗效分析 |
| 投稿时间：2017-09-11 修订日期：2017-10-13 点此下载全文 |
| 引用本文：王超,戴天阳,杨晓燕,胡智,何开明,徐涛.微波消融治疗非小细胞肺癌临床疗效分析[J].医学研究杂志,2018,47(6):130-134 |
| DOI：
10.11969/j.issn.1673-548X.2018.06.030 |
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| 中文摘要:目的 对CT引导下微波消融技术治疗周围型非小细胞肺癌患者的近期临床疗效评估。方法 纳入2015年12月~2016年12月在西南医科大学附属医院胸心外CT引导下行微波消融治疗周围性非小细胞肺癌患者31例，共33个病灶。根据肿瘤直径选择单点或多点消融，经随访评价其疗效。结果 31例患者均行微波消融术，消融后病灶CT表现为密度降低，CT值由术前49.83±10.59Hu降低为26.70±7.46Hu。其中7例获得CR，PR 6例，SD 4例，PD14例。有效率为41.94%，局部控制率54.84%。消融相关死病率0%。随访至2017年7月，中位随访时间11个月，随访率90.32%。全组平均无进展生存时间13.44±0.9个月，中位无进展生存时间为15.0个月，1年无进展生存率为55.9%。在局部进展方面，肿瘤≤3cm组与肿瘤直径>3cm组比较，差异有统计学意义。ⅡA期以前患者与ⅡA期以后患者间存在明显差异。31例患者中11例（35.48%）出现并发症包括气胸5例（16.13%），咯血2例（6.45%），胸腔积液3例（9.68%），肺炎1例（3.23%）。平均住院时间3.88±0.99天，术后住院时间1.63±0.74天，住院费用22044.76±3203.26元。结论 对于ⅡA期以前周围型非小细胞肺癌不能耐受手术的患者而言，经CT引导下微波消融术治疗是一种有效、安全性较好的治疗方案。 |
| 中文关键词:微波消融术 非小细胞肺癌 治疗 |
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| Clinical Efficacy of Microwave Ablation Treatment for Non-small Cell Lung Cancer |
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| Abstract:Objective To evaluate short-term clinical efficacy of CT guided microwave ablation treatment (MWA)for patients with peripheral non-small cell lung cancer. Methods Thirty one patients with peripheral lung cancer were treated with local anesthesia by CT-guided PMAT.There were 33 lesions in 31patients.The treatment was conducted by using single or two points' ablation emission according to the size of tumor, evaluating effect by follow-up. Results Operations were completed in 31 patients. After microwave ablation,lower density in the lesions was observed by CT with lower CT values.CT value was 49.83±10.59Hu before treatment,while it reduced to 26.70±7.46Hu after treatment.There were 7 patients with complete remission,6 cases with partial remission,4 cases with stable,14 cases with progress and effective rate of 41.94%,locoregional control rate of 54.84%, mortality of ablation related of 0%. Median follow-up of 15 months.The mean progression free survival was 13.44±0.9 months.The 1 year progression free survival was 55.9%.A significant difference was found among patients with tumors less than 3 cm and more than 3 cm, similar observation was found among patients with before ⅡA stage and after ⅡA stage.Related complications was observed including pneumothorax in 5 cases,hemoptysis in 2 cases,pleural effusion in 3 cases, pneumonia in 1 case. Mean hospitalization time was 3.88±0.99 days,postoperative hospitalization time 1.63±0.74 days,hospitalization costs 22044.76±3203.26 Yuan. Conclusion WMA is a effective,safe treatment for inoperable patients with peripheral non-small cell lung cancer before ⅡA stage. |
| keywords:Microwave ablation Non-small cell lung cancer Treatment |
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