| hTERC基因与宫颈癌发生、发展相关性 |
| 投稿时间：2017-01-09 修订日期：2017-03-24 点此下载全文 |
| 引用本文：牛艳昕,王楠.hTERC基因与宫颈癌发生、发展相关性[J].医学研究杂志,2018,47(6):164-166 |
| DOI：
10.11969/j.issn.1673-548X.2018.06.038 |
| 摘要点击次数: 646 |
| 全文下载次数: 602 |
|
|
| 中文摘要:目的 探讨分析人染色体端粒酶基因（hTERC）与宫颈癌发生、发展相关性。方法 选取笔者医院妇科收治的经阴道镜宫颈活检结果异常的患者173例，再选择同期行宫颈检查无异常的40例作为正常对照，采用荧光原位杂交技术（FISH）检测受试者宫颈脱落细胞标本hTERC基因的表达情况，并分析HPV感染与hTERC阳性率之间的关系。结果 正常对照组hTERC阳性率7.50%、CINⅠ患者hTERC阳性率15.79%、CINⅡ患者hTERC阳性率46.15%、CINⅢ患者hTERC阳性率68.63%、宫颈癌患者hTERC阳性率91.11%，随着宫颈脱落细胞病变的进程，hTERC阳性率显著递增（P<0.05）；高危型HPV感染合并hTERC阳性患者其癌前病变及癌比例为100.00%，显著高于高危型HPV感染的hTERC阳性患者以及无高危型HPV感染患者（P<0.05）。结论 hTERC基因扩增参与到了宫颈癌的发生、发展过程当中，随着宫颈病变分级的增加而呈上升趋势，hTERC基因阳性表达对宫颈癌的早期诊断具有一定的临床价值。 |
| 中文关键词:人染色体端粒酶基因 宫颈癌 宫颈病变 相关性 |
| |
| Correlation between the Human Telomerase Gene (hTERC) and the Generation and Progression of Cervical Cancer |
|
|
| Abstract:Objective To investigate the correlation between the human telomerase gene (hTERC) and the generation and progression of cervical cancer. Methods A total of 173 patients with abnormal results of cervical biopsy by colposcopy were selected, meanwhile the 40 normal cases were selected as control group. The expression of hTERC gene was detected by fluorescence in situ hybridization (FISH), and the relationship between the HPV infection and the positive rate of hTERC was analyzed. Results The positive rate of hTERC in the control group was 7.50%, which was respectively 15.79%, 46.15%, 68.63%,and 91.11% in the CIN Ⅰ group, CIN Ⅱgroup, CIN Ⅲ group, and cervical cancer group. The positive rate of the hTERC was significantly increased during the progression of cervical exfoliative cell lesions (P<0.05). The precancerous lesion and cancer rate in patients with high-risk HPV infection and positive hTERC was 100%, significantly higher than that of patients with high-risk HPV infection as well as positive hTERC and also non high-risk HPV infected patients (P<0.05). Conclusion hTERC gene amplification is involved in the development of cervical cancer, and increase with cervical lesions rising, and the positive expression of hTERC gene is valuable to the early diagnosis of cervical cancer. |
| keywords:Human telomerase gene Cervical cancer Cervical lesions Correlation |
| 查看全文 查看/发表评论 下载PDF阅读器 |
