多囊卵巢综合征体重指数与临床特征的相关性分析
投稿时间:2017-10-30  修订日期:2017-10-31  点此下载全文
引用本文:张红阳,侯丽辉,李妍,徐芳.多囊卵巢综合征体重指数与临床特征的相关性分析[J].医学研究杂志,2018,47(7):48-51
DOI: 10.11969/j.issn.1673-548X.2018.07.011
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张红阳 150040 哈尔滨, 黑龙江中医药大学  
侯丽辉 150040 哈尔滨, 黑龙江中医药大学附属第一医院妇产科 houlihui2007@sina.com 
李妍 150040 哈尔滨, 黑龙江中医药大学附属第一医院妇产科  
徐芳 150040 哈尔滨, 黑龙江中医药大学附属第一医院妇产科  
基金项目:国家中医药管理局国家中医临床研究基地业务建设科研专项基金资助项目(JDZX2012039);国家中医药管理局全国名老中医药专家传承工作室建设项目(2014-9-10);国家中医药管理局基金资助项目(JDZX2015058);黑龙江省中医药管理局基金资助项目(2HY12-W008);黑龙江省教育厅基金资助项目(12531651);黑龙江省中医药科研项目(ZHY16-029)
中文摘要:目的 探索不同体重指数的多囊卵巢综合征(PCOS)患者血清性激素及糖脂代谢水平。方法 323例PCOS患者根据体重指数分为3组,由专业人员对PCOS患者进行腰围、臀围的测量及多毛、痤疮、黑棘皮的记录,并于患者自然月经周期或孕激素撤退出血的第3~5天空腹测血清性激素、糖脂代谢水平。结果 323例PCOS患者根据体重指数(BMI)分为3组:A组(BMI<23kg/m2)、B组(23kg/m2≤BMI<25kg/m2)、C组(BMI≥25kg/m2),构成比分别为10.84%、34.67%、54.49%;腰围、臀围、腰臀比(WHR)在不同BMI中比较差异均有统计学意义(P<0.05),且腰围、臀围、WHR与BMI呈正相关。黑棘皮发生率在不同BMI组中差异有统计学意义;PCOS患者血清性激素水平在不同BMI组中比较,差异有统计学意义(P<0.05),FSH、LH和SHBG与BMI呈负相关,E2与BMI呈正相关;糖脂代谢指标在不同BMI PCOS患者中代谢水平不同,其中TG、TC、LDL、FPG、FINS和HOMA-IR均与BMI呈正相关。结论 不同BMI PCOS患者表现出血清性激素及糖代谢的差异,且FSH、LH、SHBG、E2、TG、TC、LDL、FPG、FINS水平和HOMA-IR指数均与BMI相关。
中文关键词:多囊卵巢综合征  体重指数  糖脂代谢  相关性
 
Correlation of Clinical Features and Body Mass Index in Patients with Polycystic Ovary Syndrome
Abstract:Objective to explore the levels of serum sex hormones and glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with different body mass index. Methods Totally 323 cases of PCOS were divided into three groups according to body mass index.Professional persong measured the waist circumference, hip circumference and recorded hirsutism, acne, acanthosis. In natural menstrual cycle or progesterone withdrawal bleeding 3-5 days, we measured fasting serum sex hormones and glucose and lipid metabolism. Results Totally 323 patients with PCOS were divided into three groups according to body mass index:group A (BMI<23kg/m2), group B (23kg/m22), group C (BMI ≥ 25kg/m2), accounted for 10.84%, 34.67%, 54.49%; waist and hip circumference, WHR comparison in different BMI group were statistically significant (P<0.05). Waist circumference, hip circumference, WHR was positively correlated with BMI. The occurrence of acanthosis is different in three BMI group. In patients of different BMI with PCOS, there were differences in sex hormone levels, which had statistical significance (P<0.05). BMI was negatively related to LH and SHBG, and FSH, E2 was positively associated with BMI; Glucose and lipid metabolism in different BMI PCOS in patients with different metabolic level(P<0.05). TG, TC, LDL, FPG, FINS and HOMA-IR were positively correlated with BMI. Conclusion patients with different BMI have different sex hormones and glucose metabolism. FSH,LH,SHBG,E2,TG,TC,LDL,FPG,FINS and HOMA-IR index are correlated with BMI in patients with PCOS.
keywords:Polycystic ovary syndrome  Body mass index  Glucose and lipid metabolism  Relativity
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