| HLX基因在AML中的表达及预后分析 |
| 投稿时间：2017-09-22 修订日期：2017-10-25 点此下载全文 |
| 引用本文：朱夏吟,应丽梅,朱敏,陈葆国,罗文达.HLX基因在AML中的表达及预后分析[J].医学研究杂志,2018,47(7):71-74 |
| DOI：
10.11969/j.issn.1673-548X.2018.07.017 |
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| 基金项目:浙江省医药卫生科技计划项目（2014KYB309、2017KY709） |
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| 中文摘要:目的 分析H2.0样同源盒基因（H2.0-like homeobox gene，HLX）在急性髓系白血病（acute myelogenous leukemia，AML）患者中的临床表达情况，探究HLX基因与AML疾病预后的关系。方法 收集56例AML患者的骨髓单个核细胞，实时荧光定量PCR （quantitative real-time polymerase chain reaction，qRT-PCR）检测HLX的表达水平，并结合预后基因进行分析。结果 在临床初发的AML患者中，HLX的表达水平高于正常人（P<0.01），HLX表达水平与白血病组患者年龄、骨髓原始细胞数显著相关（P<0.05），HLX表达水平与染色体核型代表的预后分层无明显关联（P>0.05）。结论 HLX基因在AML患者中的表达水平是上调的，可能拥有独立的预后信息，是AML中潜在的干预靶点。 |
| 中文关键词:HLX基因 AML 骨髓单个核细胞 预后 |
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| Expression of HLX Gene in Acute Myeloid Leukemia and Its Prognostic Analysis |
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| Abstract:Objective To analyze the expression of HLX gene in acute myeloid leukemia (AML), and to further analyze the relationship between HLX gene and prognosis. Methods The expression level of HLX was detected by qRT-PCR in bone marrow mononuclear cells which collected from 56 patients with AML, and the prognosis of patients was analyzed. Results The expression of HLX gene in AML patients was significantly higher than that in normal people (P<0.01). And it was significantly correlated with age and bone marrow primitive cells (P<0.05). What's more, there was no correlation between HLX expression and the prognosis of chromosome karyotype (P>0.05). Conclusion The expression of HLX gene in AML patients is up-regulated and may have independent prognostic information, which is a potential target for intervention in AML. |
| keywords:HLX gene AML Bone marrow mononuclear cells Prognosis |
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