| 产前超声检测胎儿静脉导管频谱与胎儿预后的关系 |
| 投稿时间：2017-09-21 修订日期：2017-10-25 点此下载全文 |
| 引用本文：王紫薇,罗红.产前超声检测胎儿静脉导管频谱与胎儿预后的关系[J].医学研究杂志,2018,47(7):84-87 |
| DOI：
10.11969/j.issn.1673-548X.2018.07.020 |
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| 基金项目:成都市科学技术局第八批科技项目（2014-HM01-00015-SF） |
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| 中文摘要:目的 探讨产前胎儿静脉导管血流频谱波形与胎儿预后的关系。方法 选取2015年1月~2016年6月在笔者医院进行常规产检的孕11~13+6周孕妇1056例作为研究对象，采用彩色多普勒超声诊断仪对胎儿行静脉导管血流频谱检查，并对所有孕妇进行随访，分析静脉导管血流频谱与胎儿预后的关系。结果 1056例胎儿中87例静脉导管频谱出现a波反流或消失，静脉导管频谱异常组胎儿先天心脏畸形、染色体异常、其他畸形的发生率分别为20.69%、8.05%、33.33%，明显高于频谱正常组0.31%、0.52%、0.93%，组间比较差异有统计学意义（P<0.05）。先天性疾病组胎儿静脉导管血流频谱的心房收缩期流速Va明显低于正常组，组间差异有统计学意义（P<0.05），而两组胎儿静脉导管血流频谱的心室收缩期流速VS、心室舒张期流速VD比较，差异无统计学意义（P>0.05）。静脉导管频谱测定对先天性疾病的诊断敏感度和特异性分别为63.04%（29/46）、94.25%（952/1010），其中对心脏畸形的诊断敏感度最高（85.71%，18/21），染色体异常的诊断敏感度次之（58.33%，7/12），其他系统畸形的诊断敏感度最低（30.77%，4/13）。结论 孕早期静脉导管血流频谱异常与胎儿先天疾病尤其是心脏畸形的关系密切，可作为早期筛查的判断标准之一。 |
| 中文关键词:静脉导管 血流频谱 产前 多普勒超声 先天性疾病 |
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| Relationship of Fetal Ductus Venosus Spectrum Examined by Prenatal Ultrasonographic and Fetal Prognosis |
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| Abstract:Objective To explore the relationship of fetal ductus venosus spectrum examined by prenatal ultrasonographic and fetal prognosis. Methods Totally 1056 pregnant women in 11-13+6 weeks gestation undergoing routine inspection in our hospital from January 2015 to June 2016 were selected as the study objects, and the fetuses were undergoing blood flow spectrum examination of venous catheter by using Color Doppler ultrasonic diagnostic apparatus. All the pregnant women were followed up, and the relationship was analyzed between blood flow spectrum of venous catheter and fetal prognosis. Results Of 1056 fetuses, there were 87 cases with a wave flowes back or disappeared in venous catheter spectrum. The incidence of fetal congenital heart malformations, chromosomal abnormalities and other malformations in the venous catheter frequency abnormality group was 20.69%, 8.05%, and 33.33% respectively, significantly higher than that of 0.31%, 0.52%, 0.93% in the normal spectrum group, with significant difference (P<0.05). Atrial systolic flow velocity of fetal venous catheter blood flow spectrum Va in the congenital disease group was significantly lower than that in the normal group, with statistically significant difference in the two groups (P<0.05). There was no significant difference in ventricular systolic flow velocity VS, ventricular diastolic flow velocity VD of Venous flow spectrum of fetuses between the two group (P>0.05). The sensitivity and specificity of diagnosis were 63.04% (29/46) and 94.25% (952/1010) respectively, in determination of congenital diseases by using venous catheter frequency, and among them, the sensitivity for cardiac malformations was the highest (85.71%,18/21), and that for chromosomal abnormalities was the second (58.33%,7/12), and that for other systemic malformations was lowest (30.77%,4/13). Conclusion Abnormal blood flow spectrum of venous catheter in early pregnancy is closely related to fetal congenital diseases, especially heart malformations. It can be used as the criteria for early screening. |
| keywords:Ductus venosus Blood flow spectrum Prenatal Doppler ultrasound Congenital diseases |
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