PON 1 192 Gln/Arg基因多态性与2型糖尿病并发冠心病风险的Meta分析
投稿时间:2017-05-03  修订日期:2017-05-14  点此下载全文
引用本文:胡道军,张莉,郁淼,秦兵.PON 1 192 Gln/Arg基因多态性与2型糖尿病并发冠心病风险的Meta分析[J].医学研究杂志,2018,47(7):100-104
DOI: 10.11969/j.issn.1673-548X.2018.07.024
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作者单位E-mail
胡道军 202150 上海交通大学医学院附属新华医院(崇明)检验科  
张莉 202150 上海交通大学医学院附属新华医院(崇明)检验科 Labzl@hotmail.com 
郁淼 202150 上海交通大学医学院附属新华医院(崇明)检验科  
秦兵 202150 上海交通大学医学院附属新华医院(崇明)检验科  
中文摘要:目的 采用Meta分析法综合评价对氧磷脂酶1 192Gln/Arg (PON1 Q192R)基因多态性与2型糖尿病并发冠心病的相关性。方法 截至2017年3月,在Pubmed、Embase、Web of Science、中国知网、万方等数据库可检索到的已发表论文,由两位评价者根据纳入排除标准独立筛选和评价文献质量。采用RevMan5.3和Stata12.0软件进行Meta分析,计算合并比值比(odds ratio,OR)及其95%可信区间(confidence intervals,CI),并进行敏感度分析和发表偏倚评估。结果 9个病例-对照研究纳入本研究,包括1353例病例组(2型糖尿病并发冠心病组)和1360例对照组(单纯2型糖尿病组)。Meta分析结果显示,与单纯糖尿病组比较,5种基因模型均提示PON1Gln/Arg基因多态性和2型糖尿病并发冠心病显著相关[等位基因模型:R vs Q,OR=1.50,95% CI (1.23~1.83);纯合子基因模型:RR vs QQ,OR=2.28,95% CI (1.52~3.42);杂合子基因模型:QR vs QQ,OR=1.42,95% CI (1.18~1.71);显性基因模型:RR+RQ vs QQ,OR=1.59,95% CI (1.33~1.89);隐性基因模型:RR vs RQ+QQ,OR=1.74,95% CI (1.24~2.45)]。人口学的亚组分析提示,对氧磷脂酶1 192Gln/Arg基因多态性与2型糖尿病并发冠心病的相关性在亚洲和高加索人群中比较,差异无统计学意义。敏感度结果显示,合并的结果是稳定可靠的,漏斗图检测未发现发表偏倚。结论 PON1 192Gln/Arg基因多态性与2型糖尿病并发冠心病风险呈显著相关性,携带R等位基因的2型糖尿病人群相对于携带Q等位基因者,可能更易并发冠心病。
中文关键词:对氧磷脂酶1 192Gln/Arg  基因多态性  2型糖尿病  冠心病  Meta分析
 
Association of Paraoxonase 1 192 Gln/Arg Gene Polymorphism and Type 2 Diabetes Mellitus with Coronary Artery Disease:Evidence from a Meta-Analysis of 9 Studies
Abstract:Objective To evaluate synthetically the association between PON1 192 Gln/Arg gene polymorphism and type 2 diabetes mellitus with coronary artery disease (T2DM-CAD). Methods We performed a meta-analysis of case-control studies by searching eligible studies in Pubmed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang databases(updated to March 31th 2017).Literatures were screened using Inclusion and Exclusion Criteria and quality assess was carried out using Newcastle-Ottawascale(NOS). This Meta-analysis was conducted by RevMan5.3 or Stata12.0 software, pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Meanwhile, sensitivity analysis and publication bias were evaluated. Results A total of 9 case-control studies were included in this Meta-analysis consisting of 1353 cases (type 2 diabetes mellitus with coronary artery disease) and 1360 controls (type 2 diabetes mellitus simply).Meta-analysis indicated that a strong association between type 2 diabetes mellitus with coronary artery disease and T2DM under 5 genetic models[R vs Q, OR (95% CI)=1.50(1.23-1.83); RR vs QQ, OR (95% CI)=2.28(1.52-3.42); QR vs QQ, OR (95% CI)=1.42(1.18-1.71); RR+RQ vs QQ, OR (95% CI)=1.59(1.33-1.89); RR vs RQ+QQ, OR (95% CI)=1.74(1.24-2.45)]. Subgroup analyses by ethnicity showed there was no significant difference existed between Asians and Caucasians. Sensitivity analysis confirmed our pooled result was stable and reliable. And publication bias was not detected by funnel plot. Conclusion Our Meta-analysis suggests that PON1 192 Gln/Arg gene polymorphism is closely related to risk of type 2 diabetes mellitus with coronary artery disease. Population with T2DM that carried R allele are more likely to suffer from concurrent coronary artery disease, comparing with those who carried Q allele.
keywords:PON1 192 Gln/Arg  Gene polymorphism  Type 2 diabetes mellitus  Coronary artery diseases  Meta-analysis
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