| 评估RDW预测COPD合并肺动脉高压发生的价值 |
| 投稿时间：2017-08-07 修订日期：2017-06-27 点此下载全文 |
| 引用本文：白艳玲,朱海燕,孙启玉,顾国忠,张灵宇,李颖,杨宝峰.评估RDW预测COPD合并肺动脉高压发生的价值[J].医学研究杂志,2018,47(8):78-81,87 |
| DOI：
10.11969/j.issn.1673-548X.2018.08.018 |
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| 基金项目:黑龙江省自然科学基金资助项目（面上项目）（H2013114） |
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| 中文摘要:目的 分析慢性阻塞性肺病（COPD）并发肺动脉高压与红细胞体积变异（RDW）的相关性。方法 以2008年1月~2014年1月笔者医院收治的103例COPD患者为观察对象，36例并发肺动脉高压患者为观察组，67例单纯COPD患者为对照组。检测两组患者的RDW值、脑钠肽（BNP）、尿酸、肺动脉收缩压（PASP）、肺功能指标和血气指标。分析两组受试者的相关指标，分析受试者的RDW值与肺功能指标、血气指标、BNP、尿酸的相关性；绘制ROC曲线评估RDW、BNP、尿酸预测COPD合并肺动脉高压发生的价值。结果 与对照组比较，观察组的RDW、动脉血二氧化碳分压（PaCO2）、PASP、BNP、尿酸水平明显升高，而动脉血氧分压（PaO2）、第1秒用力呼气容积（FEV1）、及FEV1所占用力肺活量百分比（FEV1/FVC）显著降低，差异均有统计学意义（P<0.05）。受试者的RDW与PaCO2、PASP、BNP、尿酸呈正相关，与PaO2、FEV1、FEV1/FVC呈负相关（r=0.612、0.659、0.685、0.576、-0.433、-0.630、-0.705，P均<0.05）。RDW预测COPD肺动脉高压患病的ROC曲线下面积分别为AUC=0.724、0.799、0.796，P均=0.000。结论 RDW能有效的反映COPD肺动脉高压患者的病情变化，且对COPD肺动脉高压的发生有一定的预测价值。 |
| 中文关键词:肺动脉高压 红细胞体积变异 慢性阻塞性肺病 |
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| Evaluate the Predictive Value of RDW in Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension |
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| Abstract:Objective To analyze the correlation between chronic obstructive pulmonary disease complicated with pulmonary hypertension and red blood cell distribution width (RDW). Methods One hundred and three patients with COPD in our hospital from January 2008 to January 2014 were involved as observation objects.Thirty-six patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension were involved as the observation group. Sixty-seven patients with simple chronic obstructive pulmonary disease were involved as the control group.The RDW value, brain natriuretic peptide (BNP), uric acid, pulmonary artery systolic pressure (PASP), pulmonary function index and blood gas index of two groups were detected. The related indexes of two groups were analyzed. The correlation between RDW and pulmonary function index, blood gas index, BNP and uric acid was analyzed. The ROC curve was used to evaluate the predictive value of RDW and BNP and uric acid in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension. Results Compared with the control group, the RDW, arterial partial pressure of carbon dioxide (PaCO2), PASP, BNP and uric acid value of observation group were significantly increased, while the arterial partial pressure of oxygen (PaO2), forced expiratory volume in the first second (FEV1) and the FEV1 percentage of forced vital capacity (FEV1/FVC) of observation group were decreased, the differences were statistically significant (P<0.05). RDW was positively correlated with PaCO2,PASP,BNP and uric acid value, and negatively correlated with PaO2, FEV1 and FEV1/FVC (r=0.612,0.659,0.685, 0.576, -0.433,-0.630,-0.705, all P<0.05). The area under the ROC curve and P value of RDW and BNP and uric acid predict of chronic obstructive pulmonary disease complicated with pulmonary hypertension were AUC=0.724, 0.799, 0.796, all P=0.000. Conclusion RDW can effectively reflect the changes of patients with COPD complicated with pulmonary hypertension, and it has some predictive value for COPD complicated with pulmonary hypertension. |
| keywords:Pulmonary hypertension Red blood cell distribution width Chronic obstructive pulmonary disease |
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