维生素D与新疆急性脑梗死患者神经功能缺损相关性分析
投稿时间:2017-10-16  修订日期:2017-11-06  点此下载全文
引用本文:那扎克提·努尔买买提,马建华.维生素D与新疆急性脑梗死患者神经功能缺损相关性分析[J].医学研究杂志,2018,47(8):146-149,163
DOI: 10.11969/j.issn.1673-548X.2018.08.034
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作者单位E-mail
那扎克提·努尔买买提 830054 乌鲁木齐, 新疆医科大学第一附属医院神经内科一病区  
马建华 830054 乌鲁木齐, 新疆医科大学第一附属医院神经内科一病区 mjh9191@163.com 
中文摘要:目的 研究维生素D缺乏对新疆地区急性脑梗死患者神经功能缺损程度的影响。方法 收集自2016年12月~2017年7月收治于新疆医科大学第一附属医院的156例急性脑梗死患者为病例组,同期77例健康体检者为对照组,测定其血清25-羟维生素D水平,并进行NIHSS评分评估神经功能缺损程度;比较急性脑梗死患者及健康体检者血清25-羟维生素D差异,分析血清25-羟维生素D与NIHSS评分及脑梗死面积关系,同时建立多元Logistic回归模型分析其神经功能缺损程度的关系。结果 急性脑梗死患者血清25-羟维生素D水平较健康体检组显著偏低(P<0.01);NIHSS评分与25(OH) D3水平呈负相关(P<0.01);与梗死面积不相关(P>0.05);Logistic回归分析显示血清25(OH) D3水平是影响神经功能缺损的独立危险因素(OR=0.94,95%CI:0.91~0.97,P=0.001)。结论 血清25(OH) D3参与脑梗死的发生、发展,急性脑梗死患者血清25(OH) D3水平越低,神经功能缺失程度越重,可以作为患者病情严重程度的预测指标之一。
中文关键词:血清25-羟维生素D  急性缺血性脑卒中  神经功能缺损
 
Correlation Between Serum Vitamin D and the Degree of Neurological Deficit of Acute Ischemic Stroke in Xinjiang
Abstract:Objective To observe the effect of vitamin D deficiency on the degree of neurological impairment of acute ischemic stroke. Methods The study was performed in patients with acute ischemic stroke admitted to Xinjiang Medical University Hospital from December 2016 to July 2017.Functional outcomes were evaluated with NIHSS score at admission,and divided into three different groups.In the meantime,77 healthy subjects were selected randomly as control group.Levels of the serum 25-hydroxyvitamin D values were examined. Compared the difference of the serum 25-hydroxyvitamin D levels in ischemic stroke group with that of the control group and the groups with different NIHSS scores. The correlation of the vitamin D level in ischemic stroke group with the NIHSS score were analyzed by establishing Logistic regression model. Results The serum 25-hydroxyvitamin D levels in ischemic stroke group was significantly higher than control group(P<0.01).NIHSS scores were negatively correlated with 25(OH)D3 levels (P<0.01);There is no correlation with the area of cerebral infarction.Vitamin D deficiency is an independent risk factor for neurological impairment.(OR=0.94,95%CI:0.91-0.97,P=0.001). Conclusion The serum 25-hydroxyvitamin D is involved in the development of cerebral infarction, which can be used to predict the severity of neurological impairment in acute ischemic stroke patients.
keywords:25-Hydroxyvitamin D  Acute ischemic stroke  Neurological deficit
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