| 江苏省启东市肝癌患者家族成员乙型肝炎病毒感染现状及肝功能调查 |
| 投稿时间：2017-12-12 修订日期：2017-12-18 点此下载全文 |
| 引用本文：严永锋,孙燕,薛学锋,姜小平,王金兵,吴燕,陈陶阳.江苏省启东市肝癌患者家族成员乙型肝炎病毒感染现状及肝功能调查[J].医学研究杂志,2018,47(9):49-52 |
| DOI：
10.11969/j.issn.1673-548X.2018.09.012 |
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| 基金项目:国家科技重大专项资助项目（2012ZX10002008-001，2012ZX10002008-003，2008ZX10002018-003） |
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| 中文摘要:目的 分析江苏省启东市2014~2015年来笔者医院体检的肝癌患者家族成员的乙型肝炎病毒感染现状以及部分肝功能指标。方法 收集2014年1月~2015年12月在启东市人民医院登记的肝癌患者家族成员的体检资料，分析其HBV感染情况及肝功能指标，比较不同性别家族成员的乙肝血清学标志物阳性率及肝功能指标差异，并对乙肝表面抗原阳性和阴性研究对象的部分肝功能指标异常率的差异进行了分析。结果 共纳入537例研究对象，平均年龄为45.55±14.61岁，乙肝血清学标志物HBsAg、抗-HBs、HBeAg、抗-HBe以及抗-HBc的阳性率分别为23.46%、37.24%、3.91%、14.15%和49.72%。乙肝血清学标志物阳性率的差异在男、女性性别间均无统计学意义（P>0.05）。男、女性肝功能指标中ALT、AST、DBIL、ALB、A/G、GGT和PA的比较，差异有统计学意义（P<0.05），TBIL、IBIL、TP、GLO及ALP的差异无统计学意义（P>0.05）。ALT与TBIL异常率在HBsAg阳性组与阴性组间比较，差异有统计学意义（P<0.05），而两组间TP、ALB、ALP及PA检测指标异常率比较，差异无统计学意义（P>0.05）。结论 启东市肝癌患者家族成员HBsAg携带率较高，HBsAg阳性者ALT异常率显著高于阴性者，应加强HBsAg阳性的肝癌患者家族成员的随访，定期健康体检，减少这部分人群肝癌的发生。 |
| 中文关键词:乙型肝炎病毒 肝功能 感染 肝癌家族 |
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| Investigation on HBV Infection Status and Liver Function in Family Members of Qidong Hepatocellular Carcinoma Patients in Jiangsu Province |
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| Abstract:Objective To analyze the HBV infection status and partial liver function index of family members of liver cancer patients in Qidong from 2014 to 2015. Methods We collected the medical data of the family members of HCC patients registered in Qidong People's Hospital from January 2014 to December 2015, analyzed the HBV infection and the liver function index, compared the positive rate and the liver function index of HBV serological markers in different gender family members. The difference of abnormal rate of partial liver function of HBV positive and negative subjects was analyzed. Results A total of 537 subjects were included. The mean age was (45.55±14.61), the positive rates of HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc of HBV serological markers were 23.46%, 37.24%, 3.91%, 14.15% and 49.72% respectively. The difference of positive rate of HBV serological markers was not statistically significant between males and females(P>0.05). The differences of ALT, AST, DBIL, ALB, A/G, GGT and PA were statistically significant(P<0.05), and there was no statistically significant difference in TBIL, IBIL, TP, GLO and ALP(P>0.05). The difference of ALT and TBIL abnormalities was statistically significant between the HBsAg positive group and the negative group(P<0.05), but there was no statistically significant difference in TP, ALB, ALP and PA abnormality rate between two groups(P>0.05). Conclusion The positive rate of HBsAg was higher in the family members of Qidong HCC patients. The ALT abnormality rate of HBsAg positive was significantly higher than that of negative, and the follow-up of HBsAg positive family members of hepatocellular carcinoma should be strengthened, regular health check-up should be made to reduce the occurrence of liver cancer in this group. |
| keywords:Hepatitis B virus Liver function Infection Family of liver cancer |
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