| 妊娠期脂质代谢异常与早产的关系相关研究 |
| 投稿时间：2018-06-12 修订日期：2018-07-08 点此下载全文 |
| 引用本文：张凯,谢成茂,全紫薇,蔺莉.妊娠期脂质代谢异常与早产的关系相关研究[J].医学研究杂志,2018,47(10):41-44 |
| DOI：
10.11969/j.issn.1673-548X.2018.10.012 |
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| 基金项目:国家自然科学基金资助项目（81471476） |
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| 中文摘要:目的 探讨妊娠期脂质代谢异常与早产之间的关系。方法 研究对象为2015年6月~2017年9月在首都医科大学附属北京友谊医院建档、定期产检并分娩146例，其中自发性早产50例、医源性早产47例及足月产49例。分别收集基本临床资料、胎盘组织、母体外周血及脐带血。用油红O染色法检测胎盘组织中脂质含量，用酶标法检测血液中的脂质水平；血脂水平检测包括血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL）、低密度脂蛋白胆固醇（LDL）。结果 3组患者的年龄与体重指数（BMI）比较，差异无统计学意义；自发性早产组胎盘组织中脂质含量明显低于医源性早产及足月产组（P<0.05），而医源性早产及足月产组之间差异无统计学意义；自发性早产组母体外周血中脂质含量明显低于医源性早产及足月产组（P<0.05），脐带血中除甘油三酯3组比较差异无统计学意义外，自发性早产组母体脐带血中脂质含量明显高于医源性早产及足月产组（P<0.05），而医源性早产及足月产组之间无论是外周血还是脐带血血脂水平比较，差异无统计学意义（P>0.05）。结论 早产患者母胎之间胆固醇的代谢存在紊乱现象，母胎间脂代谢异常可能是早产发生的一个诱发因素，在早产的发病过程中起到了重要的作用。 |
| 中文关键词:早产 脂质代谢 妊娠 胎盘 |
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| Abnormal Lipid Metabolism and Preterm Delivery |
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| Abstract:Objective To investigate the relationship between abnormal lipid metabolism during pregnancy and premature delivery. Methods From June 2015 to September 2017,we enrolled 146 pregnant women admitted to our hospital for regular checks as subjects,190 cases in gestational hypertension group,258 cases in gestational diabetes mellitus group.There were 50 cases of spontaneous premature delivery, 47 cases of iatrogenic preterm delivery and 49 cases of preterm delivery. The basic clinical data, placental tissue, maternal peripheral blood and umbilical cord blood were collected. The lipid content in the placenta tissue was detected by oil red O staining, and the lipid levels in the blood were detected by enzyme labeling, and the level of blood lipid included serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL) and low density lipoprotein cholesterol (LDL). Results There was no significant difference in age and body mass index (BMI) between the three groups. The lipid content in the placental tissue of the spontaneous premature birth group was significantly lower than that of the iatrogenic preterm birth and the full term birth group (P<0.05), but there was no significant difference between the iatrogenic preterm delivery and the full term birth group, and the lipid content in the maternal peripheral blood of the spontaneous premature birth group was significantly lower. The maternal umbilical cord blood lipid content was significantly higher than that of iatrogenic preterm labor and full term birth group (P<0.05) in the three groups of umbilical cord blood and blood, except for the triglyceride group (P<0.05). There was no significant difference between the two levels (P>0.05). Conclusion There is a disorder in the metabolism of cholesterol in the mother fetus of premature birth, and abnormal lipid metabolism in the mother fetus may be an inducing factor of preterm birth, which plays an important role in the process of premature birth. |
| keywords:Preterm delivery Lipid metabolism Pregnancy Placenta |
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