| 结直肠息肉与非酒精性脂肪性肝病的相关性研究 |
| 投稿时间：2017-12-01 修订日期：2017-12-19 点此下载全文 |
| 引用本文：刘姗,冯玉良,王卫峰,朱琴,郑培奋.结直肠息肉与非酒精性脂肪性肝病的相关性研究[J].医学研究杂志,2018,47(10):150-153 |
| DOI：
10.11969/j.issn.1673-548X.2018.10.038 |
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| 中文摘要:目的 探讨结直肠息肉与非酒精性脂肪性肝病的相关性。方法 回顾性分析2017年2月1日~2017年7月1日在浙江医院消化内科门诊及住院期间进行肠镜检查发现的94例结直肠息肉患者作为病例组及135例无息肉组作为对照组，比较分析两组人群的一般临床特征、甘油三酯、总胆固醇、低密度脂蛋白、空腹血糖水平、幽门螺杆菌感染情况、非酒精性脂肪性肝病发生率等。结果 与对照组比较，病例组的甘油三酯、总胆固醇、低密度脂蛋白均明显升高（甘油三酯2.90±1.36mmol/L vs 2.03±11.00mmol/L，t=-4.417；总胆固醇3.33±0.45mmol/L vs 4.40±0.64mmol/L，t=-12.417；低密度脂蛋白3.33±0.45mmol/L vs 2.54±0.46mmol/L，t=-12.926，P均<0.01）。病例组非酒精性脂肪性肝病发生率为46.81%，对照组NAFLD发生率为15.56%。两组间性别、年龄、空腹血糖、幽门螺杆菌感染率比较差异无统计学意义（P>0.05）。多因素回归分析显示，非酒精性脂肪性肝病是结直肠息肉的风险因素（OR=2.342，95% CI：1.324~2.621）。结论 结直肠息肉和非酒精性脂肪性肝病患病相关，结直肠息肉患者需要加强腹部B超随访。 |
| 中文关键词:结直肠息肉 非酒精性脂肪性肝病 代谢综合征 |
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| A Study on the Relationship Between Colorectal Polyps and Non-alcoholic Fatty Liver Disease |
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| Abstract:Objective To explore the association between colorectal polyps and nonalcoholic fatty liver disease. Methods This retrospective cohort observational study conducted at department of gastroenterology, Zhejiang Hospital from February 1st 2017 to July 1st 2017. Patients who underwent colonoscopy were divided into case group(94 patients with colorectal polyps) and control group(135 patients without colorectal polyps). Data were extracted from the patient charts including demographic, triglyceride, cholesterol, low density lipoprotein, fast glucose, helicobacter pylori infection. Results Compared with those of control group, the levels of triglyceride, cholesterol and low density lipoprotein in colorectal polyps group were increased significantly (triglyceride 2.90±1.36mmol/L vs 2.03±11.00mmol/L,t=-4.417; cholesterol 3.33±0.45mmol/L vs 4.40±0.64mmol/L, t=-12.417; low density lipoprotein 3.33±0.45mmol/L vs 2.54±0.46mmol/L, t=-12.926; P all <0.01). The prevalence of nonalcoholic fatty liver disease was 46.81% in the colorectal polyps group and 15.56% in the control group. There was no significant difference in glucose and helicobacter pylori infection between case group and control group(P all >0.05). By multiple regression analysis, nonalcoholic fatty liver disease was found to be associated with an increased risk of colorectal polyps(OR=2.342; 95% confidential interval:1.324-2.621). Conclusion Our study found a possible association between nonalcoholic fatty liver disease and colorectal polyps. It was necessary for these patients to strengthen abdominal ultrasonic examination. |
| keywords:Colorectal polyps Nonalcoholic fatty liver disease Metabolic syndrome |
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