坦索罗辛联合索利那新对比坦索罗辛单药治疗下尿路症状有效性的Meta分析
投稿时间:2018-02-01  修订日期:2018-03-10  点此下载全文
引用本文:曹伟伟,陈洁,王绍江.坦索罗辛联合索利那新对比坦索罗辛单药治疗下尿路症状有效性的Meta分析[J].医学研究杂志,2018,47(12):69-74
DOI: 10.11969/j.issn.1673-548X.2018.12.017
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作者单位E-mail
曹伟伟 510630 广州, 暨南大学附属第一医院泌尿外科  
陈洁 510630 广州, 暨南大学附属第一医院泌尿外科 568161322@qq.com 
王绍江 510630 广州, 暨南大学附属第一医院泌尿外科  
基金项目:广东省中医药管理局科研项目(20151180)
中文摘要:目的 系统评价坦索罗辛联合索利那新对比单用坦索罗辛治疗前列腺增生症(benign prostatic hyperplasia,BPH)并发下尿路症状(lower urinary tract symptoms,LUTS)的有效性,为临床上BPH并发的难治性LUTS提供循证依据。方法 循证检索英文数据库如PubMed、Cochrane Library、EMBase等,以及中文数据库如CNKI、CBM、万方数据库等,手工检索国内相关杂志。提取数据,运用Review Manager 5.3进行数据统计。结果 根据制定的纳入及排除标准一共筛选出10项研究,共968例病例,经过基线检验,治疗前各组差异均无统计学意义。结果显示,坦索罗辛联合索利那新对比坦索罗辛单药治疗BPH所致的LUTS能更好的降低前列腺症状评分(IPSS)、膀胱过度活动评分(OABSS)及生活质量评分(QOL),但在残余尿量(PVR)和最大尿流率(QMAX)方面,两种治疗方式的差异无统计学意义。结论 坦索罗辛联合索利那新在治疗BPH并发的LUTS症状、提高患者生活质量方面要优于坦索罗辛单药方案,并且不会增加排尿困难的风险。
中文关键词:下尿路症状  坦索罗辛  索利那新  Meta分析  前列腺增生症
 
Effect of Combine the Tamsulosin with Solifenactin Versus Tamsulosin Monotherapy in the Treatment of the Lower Urinary Tract Symptoms: A Meta-analysis
Abstract:Objective To evaluate the efficacy of tamsulosin combined with solifenacin versus tamsulosin alone in the treatment of benign prostatic hyperplasia(BPH)complicated with lower urinary tract symptoms(LUTS). Methods Relevent randomized controlled trials(RCTs) were searched in database including PubMed, Cocharane Library, Web of Science, EMBase, CNKI, CBM, Wangfang. The data were extracted, quality of studies was evaluated according to the Cochrane handbook, Review Manager 5.3 software used for this Meta-analysis. Results A total of 968 patients were screened out according the established inclusion and exclusion criteria. After baseline examination, there was no significant difference between the two groups before treatment. Tamsulosin combined with solifenacin versus tamsulosin alone in the treatment of BPH complicated with lower urinary tract symptoms can better reduce the prostate symptom score, reduce the bladder over-activity score, reduce the quality of life score. However, there was no statistically significant difference between the two treatments in improving residual urine and maximum urinary flow rates. Conclusion The effect of tamsulosin combined with solifenacin in the treatment of BPH of LUTS symptoms and improving patient quality of life are better than tamsulosin alone, and will not increase the risk of dysuria.
keywords:Lower urinary tract symptoms  Tamsulosin  Solifenacin  Meta-analysis  Benign prostatic hyperplasia
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