| 彩色多普勒血流参数与Graves甲状腺功能亢进131I治疗疗效的相关性分析 |
| 投稿时间：2018-03-11 修订日期：2018-04-10 点此下载全文 |
| 引用本文：李真真,张周龙.彩色多普勒血流参数与Graves甲状腺功能亢进131I治疗疗效的相关性分析[J].医学研究杂志,2018,47(12):145-148,134 |
| DOI：
10.11969/j.issn.1673-548X.2018.12.033 |
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| 基金项目:河南省洛阳市科技攻关项目（1603001A-10） |
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| 中文摘要:目的 回顾性分析Graves甲状腺功能亢进（以下简称甲亢）患者131I治疗前甲状腺上动脉血流参数、甲状腺重量、摄碘率对131I治疗疗效的影响及预测能力评估。方法 收集在笔者医院确诊为Graves甲亢并行131I治疗的患者共74例，以治疗后6个月复查的血清学检查结果将上述患者分为复发组、缓解组、甲减组，对甲状腺上动脉的收缩期峰值血流速度（PSV）、舒张末期血流速度（EDV）、阻力指数（RI）、搏动指数（PI）、收缩期加速时间（SAT）和心率（HR）、甲状腺重量、摄碘率进行单因素、多因素统计学分析。结果 多元线性逐步回归显示PSV、EDV、RI、HR、SAT、PI、甲状腺重量及6h摄碘率为影响预后的独立影响因素，其中PSV对预后的影响最大，其次为SAT。结论 对于PSV、甲状腺重量、PI、RI及6h摄碘率高，SAT低的的患者，其治愈率低，应适当增加131I剂量以尽量达到完全缓解，而对于PSV、甲状腺重量、PI、RI及6h摄碘率低，SAT高的患者，其甲状腺功能减退（以下简称甲减）发生率高，应适当减少剂量以避免甲减并发症的出现。 |
| 中文关键词:Graves甲亢 甲状腺上动脉血流参数 相关性分析 |
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| Correlation Analysis of Color Doppler Blood Flow Parameters and Therapeutic Effect of Graves Hyperthyroidism 131I |
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| Abstract:Objective To study the effect of superior thyroid artery blood flow parameters, thyroid weight and 131I uptake rate on the efficacy of 131I treatment and the predictive ability of Graves hyperthyroidism before and after 131I treatment. Methods A total of 74 patients with Graves hyperthyroidism treated with 131I in our hospital were collected. The patients were divided into uncured group, remission group and hypothyroidism group according to the results of serological examination 6 months after treatment. The peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI), pulsatile index (PI), systolic acceleration time (SAT), heart rate (HR), thyroid weight and 131I rate of superior thyroid artery were analyzed by univariate and multivariate statistical analysis. Results Multiple linear stepwise regression showed that PSV, EDV, RI, HR, SAT, PI, thyroid weight and 6h 131I rate were independent prognostic factors, and PSV had the greatest impact on prognosis, followed by SAT. Conclusion For PSV, PI, RI, thyroid weight and 6h iodine uptake rate was high, low SAT patients, the cure rate was low, should be appropriate to increase the dose of 131I in order to achieve a complete remission, but for PSV, PI, RI, thyroid weight and 6h iodine uptake rate was low, the patients with high SAT, the incidence rate of hypothyroidism high, there should be appropriate to reduce the dose to avoid complications of hypothyroidism. |
| keywords:Graves hyperthyroidism Blood flow parameters of the superior thyroid artery Correlation analysis |
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