| 氨基末端脑钠肽前体与冠状动脉病变相关性分析 |
| 投稿时间：2014-06-24 修订日期：2014-07-01 点此下载全文 |
| 引用本文：王欣,夏豪,童随阳,李磊.氨基末端脑钠肽前体与冠状动脉病变相关性分析[J].医学研究杂志,2015,44(1):47-50,138 |
| DOI：
10.3969/j.issn.1673-548X.2015.01.014 |
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| 基金项目:国家自然科学基金资助项目(81270184) |
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| 中文摘要:目的 探讨氨基末端脑钠肽前体(NT-proBNP)与冠状动脉病变的相关性。方法 入选笔者医院2012年6月~2014年2月诊断为急性ST段抬高型急性心肌梗死(ST-elevation myocardial infarction,STEMI)患者157例,根据患者血中NT-proBNP水平分为NT-proBNP正常组(NT-proBNP<780pg/ml) 78例、NT-proBNP升高组(NT-proBNP>780pg/ml)79例。统计患者入院基本临床资料,所有患者均检测肌钙蛋白(cTnI)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),根据冠状动脉狭窄直径≥50%累及左前降支(LAD)、左回旋支(LCX)、右冠状动脉(RCA)或左主干(LM)分为单支、双支(累及左主干为双支病变)及3支病变组,根据Gensini积分标准对每位患者冠状动脉病变进行评分。计量资料采用均数±标准差(x ±s)表示,组间比较采用两独立样本t检验,计数资料采用率表示,组间比较用χ2检验,NT-proBNP水平与冠状动脉Gensini积分相关性采用线性相关分析。结果 与NT-proBNP正常组相比,NT-proBNP升高组患者冠状动脉病变情况在总体上差异有统计学意义(P=0.000),以冠状动脉无病变组作为对照组,单支病变组、两支/左主干病变组和3支病变组与对照组相比,差异均有统计学意义(P=0.004,P=0.000,P=0.000);NT-proBNP升高组患者平均冠状动脉病变支数更多(1.22±0.84 vs 2.08±0.82,P=0.000),Gensini积分更高(24.83±22.31 vs 54.60±29.13,P=0.000);NT-proBNP与Gensini积分存在相关关系(r=0.648,P=0.000)。结论 冠状动脉病变程度与NT-proBNP存在一定关系,可以用血中NT-proBNP水平预测冠状动脉病变程度。 |
| 中文关键词:氨基末端脑钠肽前体 急性ST段抬高型急性心肌梗死 冠状动脉病变 |
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| Correlation between NT-proBNP and Coronary Artery Lesions |
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| Abstract:Objective To explore the correlation between NT-proBNP and coronary arterty lesions. Methods Totally 157 patients were diagnosed coronary heart disease (CHD) from June 2012 to February 2014 in our hospital.Patients were divided into NT-proBNP normal group (78 cases) or NT-proBNP elevatory group(79 cases) according to the level of NT-proBNP. 157 patients diagnosed of CHD were studied basic clinical charateristics.cTnI,fasting blood glucose,total cholesterol, triglycerides, high density lipoprotein cholesterol and low density liporotein cholesterol were determined in all the patients.All patients were divided into none vessel lesions,1 vessel lesions,2 vessels lesions or large main vessel lesions,3 vessels lesions groups according to stenosis of major vessels≥50%. We evaluated every patient coronary lesions according to Gensini score criteria.The quantitative data were expressed by x ±s and the qualitative data were expressed by rete.The quantitative data comparison between the groups was used independent-samples t test and the quantitative data comparison between grounps was used chi-square test,and the correlation between NT-proBNP and coronary artery lesions Gensini score was used linear correlation analysis. Results On the whole, there is statistical significance (P=0.000) in Coronary artery lesions in patients with NT-proBNP normal group and NT-proBNP group. Compared with none coronary atery lesions,1 vessel lesions,2 or left main vessels lesions and 3 vessel lesions have statistical significance(P=0.004,P=0.000,P=0.000).Compared with NT-proBNP normal group,the average coronary artery lesions and Gensini score of every patients in SAP group is higher(P<0.05). NT -proBNP was correlated with the Gensini score. Conclusion There is correlation between NT-proBNP levels and coronary artery lesions, and the NT-proBNP levels can be used to predict the severity of coronary artery lesions. |
| keywords:NT-proBNP ST-elevation myocardial infarction Coronary artery lesions |
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