| 同型半胱氨酸与2型糖尿病颈动脉斑块稳定性的关系 |
| 投稿时间：2014-11-19 修订日期：2014-11-25 点此下载全文 |
| 引用本文：修双玲,王立,孙丽娜,鲁梅花.同型半胱氨酸与2型糖尿病颈动脉斑块稳定性的关系[J].医学研究杂志,2015,44(6):107-109 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.030 |
| 摘要点击次数: 1628 |
| 全文下载次数: 1541 |
|
|
| 中文摘要:目的 探讨血浆同型半胱氨酸水平与2型糖尿病患者颈动脉斑块稳定性的关系。方法 选取2型糖尿病患者182例,根据颈动脉超声结果分为无斑块组、稳定斑块组、不稳定斑块组及血管狭窄组。观察4组患者的同型半胱氨酸、血糖、血脂、糖化血红蛋白及CRP等指标。结果 动脉狭窄组同型半胱氨酸水平明显高于另外3组(P<0.01),无斑块组同型半胱氨酸水平与不稳定斑块组及动脉狭窄组比较明显降低(P<0.01)。高同型半胱氨酸组脑卒中发生率明显高于低同型半胱氨酸组(P<0.05)。相关分析显示,糖尿病患者的血浆同型半胱氨酸水平与年龄呈正相关(r=0.15,P=0.040),与叶酸呈负相关(r=-0.32,P=0.001)。结论 2型糖尿病患者血同型半胱氨酸水平与颈动脉斑块稳定性及脑卒中发生密切相关。 |
| 中文关键词:同型半胱氨酸 糖尿病 颈动脉 动脉粥样硬化 |
| |
| Relationship Between Homocysteine and the Stability of Carotid Atherosclerotic Plaque in Patients with Type 2 Diabetes |
|
|
| Abstract:Objective To investigate the relationship between plasma homocysteine level and the stability of carotid atherosclerotic plaque in patients with type 2 diabetes. Methods A total of 182 patients with type 2 diabetes were assigned to four groups according to the results of the ultrasonography of carotid artery, that was non-plaque group, stable plaque group, instable plaque group and carotid artery stenosis group. The levels of plasma homocysteine, blood glucose, blood lipid, glycosylated hemoglobin and C-reactive protein of the patients were observed. Results The plasma homocysteine levels of patients in the carotid artery stenosis group were significantly higher than patients in the other 3 groups(P<0.01).Compared to the patients in the instable plaque group and carotid artery stenosis group, the plasma homocysteine levels of patients in the non-plaque group were significantly lower(P<0.01).The levels of homocysteine in type 2 diabetes were positively correlated with age (r=0.15,P=0.040)and negatively correlated with the levels of serum folic acid(r=-0.32, P=0.001). Conclusion The plasma homocysteine levels of type 2 diabetes were closely related with the the stability of carotid atherosclerotic plaque and the incidence of stroke. |
| keywords:Homocysteine Diabetes Carotid artery Atherosclerosis |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
