| 高压氧辅助治疗小儿病毒性脑炎的效果及其对神经相关蛋白、脑过氧化反应的影响 |
| 投稿时间：2014-11-12 修订日期：2014-12-03 点此下载全文 |
| 引用本文：潘美红,沈金月.高压氧辅助治疗小儿病毒性脑炎的效果及其对神经相关蛋白、脑过氧化反应的影响[J].医学研究杂志,2015,44(6):119-122 |
| DOI：
10.11969/j.issn.1673-548X.2015.06.034 |
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| 中文摘要:目的 探讨高压氧辅助治疗小儿病毒性脑炎的效果及其对神经相关蛋白、脑过氧化反应的影响。方法 选择笔者医院2010年4月~2013年12月收治的小儿病毒性脑炎患者78例,全部患儿随机分为两组,对照组患者给予常规治疗,研究组患者在常规治疗的基础上给予高压氧辅助治疗;治疗2周后评价两组治疗效果,治疗前后检测患儿血清神经元特异性烯醇化酶(NSE)、β-内啡肽(β-EP)、髓鞘碱性蛋白(MBP)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)水平,并进行组间比较。结果 研究组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。研究组患儿头痛消失时间、呕吐消失时间、意识清醒时间明显短于对照组,组间差异有统计学意义(P<0.05); 治疗前两组患儿血清NSE、β-EP、MBP、SOD、MDA差异无统计学意义(P>0.05)。治疗后研究组NSE、β-EP、MBP、MDA明显低于对照组,SOD水平明显高于对照组,差异均有统计学意义(P<0.05)。结论 高压氧辅助治疗小儿病毒性脑炎效果良好,可有效增加脑氧供,改善脑代谢,减轻脑细胞脂质过氧化反应,对促进神经细胞功能恢复有积极作用。 |
| 中文关键词:高压氧 病毒性脑炎 神经细胞功能 过氧化反应 |
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| Effect of Hyperbaric Oxygen Adjuvant Therapy in Children with Viral Encephalitis and Its Influence on Nerve-related Proteins, Brain Peroxidation Reaction |
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| Abstract:Objective To explore the effect of hyperbaric oxygen adjuvant therapy in children with viral encephalitis and its influence on nerve-related proteins, brain peroxidation reaction. Methods Seventy-eight cases of pediatric patients with viral encephalitis in our hospital from April 2010 to December 2013 were divided into two groups according to whether receive hyperbaric oxygen therapy. The patients in control group were given conventional treatment, and patients in research group were given hyperbaric oxygen adjuvant therapy on the basis of conventional therapy. After two weeks treatment, the effect of two groups were evaluated. Before and after treatment, the serum neuron-specific enolase (NSE), β-endorphin (β-EP), myelin basic protein (MBP), superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels of two groups were detected and compared. Results The total efficiency rate of research group was significantly higher than control group, and the difference was statistically significant (P<0.05). The headache extinction time, vomiting disappearance time, conscious recover time of research group were significantly shorter than control group, and difference between the groups was significant (P<0.05). Before treatment, serum NSE, β-EP, MBP, SOD, MDA between two groups were not significantly different, but after treatment, NSE, β-EP, MBP, MDA of research group was significantly lower than the control group, SOD levels were significantly higher, and the difference was statistically significant (P<0.05). Conclusion Effect of hyperbaric oxygen adjuvant therapy in children with viral encephalitis is good, can effectively increase oxygen supply of brain, improve brain metabolism, reduce lipid peroxidation reaction of brain cells, has positive effect on functional recovery of nerve cells. |
| keywords:Hyperbaric oxygen Viral encephalitis Nerve cell function Peroxidation reaction |
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