| 湖南地区人群GSTM1和GSTT1基因多态性与结直肠癌遗传易感性分析 |
| 投稿时间：2015-08-06 修订日期：2015-09-25 点此下载全文 |
| 引用本文：曾丽平,吴和平,舒筱灿,舒旭,杨美兰,曾文明.湖南地区人群GSTM1和GSTT1基因多态性与结直肠癌遗传易感性分析[J].医学研究杂志,2016,45(3):61-65 |
| DOI：
10.11969/j.issn.1673-548X.2016.03.017 |
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| 基金项目:湖南省教育厅科研基金资助项目(12C1193);湖南医药学院校级科研基金资助项目(2012KY04) |
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| 中文摘要:目的 探讨代谢酶GSTM1和GSTT1基因多态性与湖南地区人群结直肠癌遗传易感性之间的关系.方法 采用以医院为基础的病例-对照研究,应用PCR方法对108例结直肠癌患者和215例正常人群的GSTM1和GSTT1基因型进行检测和分析.结果 GSTM1基因在结直肠癌组和对照组中的缺失率分别为64.8%和 48.8%,且两组之间差异具有统计学意义(P<0.05),以GSTM1(+)为参照,GSTM1(-)者结直肠癌发病风险增加2.6倍.GSTT1基因在结直肠癌组和对照组中的缺失率分别为55.6%和45.6%,两组之间差异无统计学意义(P>0.05).GSTM1和GSTT1基因型之间可能存在联合作用,同时携带GSTM1(-)和GSTT1(-)者比同时携带GSTM1(+)和GSTT1(+)者结直肠癌发病风险增加3.88倍.GSTM1(-)和GSTT1(-)与吸烟在结直肠癌的发病中具有协同作用,与不吸烟者比较,其OR值分别为7.76和6.24.结论 GSTM1基因缺失与本地区人群结直肠癌发病风险相关,GSTT1基因缺失与本地区人群结直肠癌发病风险无关,GSTM1和GSTT1同时缺失者结直肠癌发病风险更高,GSTM1和GSTT1基因缺失与吸烟在结直肠癌的发病中具有协同作用. |
| 中文关键词:结直肠癌 基因多态性 易感性 谷胱甘肽硫转移酶 |
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| Association between Genetic Polymorphism of GSTM1 and GSTT1 and Susceptibility to Colorectal Cancer in Hunan Province. |
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| Abstract:Objective To evaluate the association between genetic polymorphism of GSTM1 and GSTT1 and susceptibility to colorectal cancer in Hunan province. Method It was a hospital-based case-control study. Genotypes of GSTM1 and GSTT1 were detected using PCR technique from 108 cases with colorectal cancer and 215 healthy controls. Results The frequencies of GSTM1-null genotype were 64.8% in case group and 48.8% in control group, and significant difference between these two groups was observed. Compared with GSTM1(+) genotype, persons with GSTM1(-) genotype had 2.6-fold increased risk for developing colorectal cancer. The frequencies of GSTT1-null genotype were 55.6% in case group and 45.6% in control group, and no significant difference between these two groups was observed. The GSTM1 and GSTT1 may had combined action, persons with both GSTM1(-) and GSTT1(-) genotypes had 3.88-fold increased risk for developing colorectal cancer than those with both GSTM1(+) and GSTT1(+) genotypes.GSTM1(-) genotype or/and GSTT1(-) genotype interacted with smoking in the carcinogenesis process of colorectal cancer (OR=7.76 and 6.24). Conclusion These results suggested that GSTM1-null genotype may associate with the risk of colorectal cancer, but GSTT1-null genotype is not associated with the risk of colorectal cancer. Persons with both GSTM1(-) and GSTT1(-) genotypes may be associated with the risk of colorectal cancer. GSTM1(-) genotype or/and GSTT1(-) genotype interacted with smoking in the carcinogenesis process of colorectal cancer. |
| keywords:Colorectal cancer Gene polymorphism Susceptibility Glutathione S-transferase |
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