| E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义 |
| 投稿时间：2015-09-25 修订日期：2015-11-17 点此下载全文 |
| 引用本文：郑彩云,汪鹏,沈显军,王舒仪,郑海红,施更生.E-cadherin和Slug在口腔鳞状细胞癌中的表达及临床意义[J].医学研究杂志,2016,45(5):115-119 |
| DOI：
10.11969/j.issn.1673-548X.2016.05.028 |
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| 基金项目:台州市医学会研究基金资助项目(TZSYXH15-13) |
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| 中文摘要:目的 研究E-cadherin和Slug在口腔鳞状细胞癌(OSCC)组织中的表达及临床意义。方法 采用免疫组织化学DAB显色法检测74例OSCC组织切片和30例正常口腔黏膜组织切片中E-cadherin和Slug的表达,分析E-cadherin与Slug在OSCC和正常口腔黏膜组织中的表达及E-cadherin与Slug的异常表达与临床病理特征之间的关系。结果 在OSCC组织中E-cadherin和Slug的阳性表达率分别为52.63%(40/74)和48.65%(36/74)。结合OSCC临床病理特征发现,E-cadherin的表达与肿瘤病理分级、淋巴结转移有统计学意义(P<0.05),Slug的表达与肿瘤病理分级、TNM分期、淋巴结转移有统计学意义(P<0.05),同时发现OSCC组织中E-cadherin的表达与Slug的表达呈负相关(r=-0.513,P<0.05)。结论 E-cadherin和Slug的表达异常可能与OSCC的发生、发展、转移相关,其二者的联合检测可作为判断OSCC恶性程度和预后的参考指标。 |
| 中文关键词:E-cadherin Slug EMT 口腔鳞状细胞癌 免疫组织化学 |
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| Expression and Clinical Significance of E-cadherin and Slug in Oral Squamous Cell Carcinoma |
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| Abstract:Objective To explore the expression and the prognostic significance of E-cadherin and Slug in oral squamous cell carcinoma(OSCC)tissues. Methods We analyzed the E-cadherin,Slug expression in 74 patients with OSCC and 30 normal oral tissue by means of immunohistochemistry. Results E-cadherin,slug positive expression rate in OSCC was 52.63(40/74) and 48.65%(36/74).The results of clinical and pathological characteristics in OSCC showed that the expression of E-cadherin were associated with pathological and lymph node metastasis(P<0.05),while the the expression of Slug were associated with pathological,TNM stage and lymph node metastasis(P<0.05).The results also suggested that the expression of E-cadhein and Slug had a negative correlation(r=-0.513,P<0.05). Conclusion Expression of E-cadherin and Slug may correlate with occurrence,development and metastasis of OSCC.The expression of E-cadherin and Slug can be regarded as valuable indicators for evaluating biological behavior and the prognosis of OSCC. |
| keywords:E-cadherin Slug EMT Oral squamous cell carcinoma Immunohistochemisty |
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