| 砖茶型氟铝联合中毒大鼠脑氧化应激水平变化 |
| 投稿时间：2015-09-29 修订日期：2015-10-10 点此下载全文 |
| 引用本文：孙中蕾,白静,陈瑶,刘庆斌,刘晓波.砖茶型氟铝联合中毒大鼠脑氧化应激水平变化[J].医学研究杂志,2016,45(7):33-35 |
| DOI：
10.11969/j.issn.1673-548X.2016.06.010 |
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| 基金项目:内蒙古自治区科技厅人口健康科技支撑项目（20110502） |
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| 中文摘要:目的 通过对长期大量饮用砖茶大鼠脑组织丙二醛、谷胱甘肽过氧化物酶、谷胱甘肽S转移酶和总超氧化物歧化酶含量的检测，探讨砖茶型氟铝联合中毒发生的病理生理学机制，并为长期饮用砖茶地区氟铝联合中毒的预防提供参考。方法 5周龄SPF级Wistar大鼠70只，雌雄各半，随机分为7组，分别为正常对照组、氟组、铝组、氟铝组、高剂量高氟高铝砖茶组、低剂量高氟高铝砖茶组、低氟低铝砖茶组。12个月时处死大鼠，通过检测大鼠脑组织MDA含量及T-SOD、GSH-PX、GST的活力，来评价其氧化应激水平。结果 各化学剂量组大鼠脑组织T-SOD、GSH-PX、GST均显著低于对照组（P<0.01），氟组和铝组MDA均显著高与对照组（P<0.01），高剂量高氟高铝砖茶组GSH-PX（P<0.01），GST（P<0.01）均显著高于对照组，低氟低铝砖茶组T-SOD（P<0.01）、GSH-PX（P<0.01）均显著高于对照组。结论 氟和铝之间可能存在拮抗作用，低氟低铝砖茶组具有很好的抗氧化作用，可提倡饮用低氟低铝砖茶。 |
| 中文关键词:砖茶|氟铝联合|氧化应激|机制 |
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| Oxidative Stress in the Rat Brain with the F-Al Combined Toxicosis Caused by Drinking Brick Tea |
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| Abstract:Objective To detect MDA,GSH-PX,GST and T-SOD about the brain tissue of the rat. Methods Wistar rats were 5-week.7 groups were divided randomly, with 10 rats in each group. Male and female were both half. There were normal control group, fluorine group, aluminum group, fluorine and aluminum group,high-dose fluoride-aluminum brick tea group, low-dose fluoride-aluminum brick tea group,low fluorine and low aluminum brick tea group.The rat will be killed at the end of 12 months. Then the brain tissue will be detected. Results T-SOD, GSH-PX, GST in each chemical dose group were significantly lower than those in the control group（P<0.01）.MDA in fluorine group and aluminum group was higher than the control group（P<0.01）.GSH-PX(P<0.05), GST（P<0.01）. in high-dose fluoride-aluminum brick tea group is higher than the control group.T-SOD（P<0.01）, GSH-PX(P<0.05) in Low fluorine and low aluminum brick tea group was higher than the control group. Conclusion Antagonism may be existed between fluoride and aluminum. Low fluorine and low aluminum brick tea has good ability of antioxidant. Therefore we can advocate to drink low fluorine and low aluminum brick tea. |
| keywords:Brick tea|F-Al combined toxicosis|Oxidative stress|Mechanism |
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