| 不同剂量顺阿曲库铵预处理对琥珀胆碱所致肌颤和肌痛的影响 |
| 投稿时间：2015-12-15 修订日期：2015-12-29 点此下载全文 |
| 引用本文：张冬生,张荦,张转,刘旭红,眭伟,孙建宏.不同剂量顺阿曲库铵预处理对琥珀胆碱所致肌颤和肌痛的影响[J].医学研究杂志,2016,45(7):124-127 |
| DOI：
10.11969/j.issn.1673-548X.2016.07.033 |
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| 中文摘要:目的 探讨不同剂量顺阿曲库铵预处理对琥珀胆碱所致肌颤和肌痛的影响。方法 择期全身麻醉下行腹腔镜胆囊切除术患者90例，根据顺阿曲库铵不同预处理剂量分为Ⅰ组（0.005mg/kg）、Ⅱ组（0.01mg/kg）、Ⅲ组（0.02mg/kg）共3组，每组30例。使用预处理药后3.5min时静脉注射全身麻醉诱导药物，4.5min时行4个成串刺激（train of four，TOF）监测，5min时静脉注射琥珀胆碱1.5mg/kg，6.5min时行气管插管。监测注射顺阿曲库铵后不良反应的发生、各组肌颤程度、气管插管条件、TOF最大抑制及20%恢复时间、以及术后24h肌痛程度的变化。结果 Ⅲ组肌颤显著减轻（P<0.05），其余两组肌颤差异无统计学意义（P >0.05）；各组气管插管条件、TOF最大抑制及20%恢复时间差异均无统计学意义（P >0.05）；术后24h各组均发生肌痛，组间差异无统计学意义（P >0.05）。Ⅲ组于3min时产生暂时性复视及睁眼困难（P<0.05）。结论 在给予琥珀胆碱前5min时，预先注射0.02mg/kg顺阿曲库铵可显著减轻琥珀胆碱所致肌颤，不影响其肌松效应及气管插管条件，对术后24h肌痛无显著影响，但可产生暂时性复视及睁眼困难等不良反应。 |
| 中文关键词:顺阿曲库铵|琥珀胆碱|肌颤|肌痛 |
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| Effects of Pretreatment with Different Doses of Cisatracurium on Succinylcholine-induced Fasciculations and Myalgia |
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| Abstract:Objective To compare the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations and myalgia. Methods Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02mg/kg cisatracurium, respectively. After the pretreatments, general anesthesia was induced 3.5min later, train of four stimulation was monitored 4.5min later, succinylcholine 1.5mg/kg was injected 5min later, and endotracheal intubation was implemented 6.5min later. Side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, and severity of myalgia at 24 hours postoperatively were recorded. Results Fasciculations were alleviated significantly after the cisatracurium pretreatment of 0.02mg/kg than the other two doses (P<0.05). Intubating conditions, time and extent to maximal depression of twitch, time for its recovery to 20% of the controls, and incidence of myalgia at 24h postoperatively had no significant changes among the three groups (P >0.05). Transient diplopia and difficulty to open eyes emerged after pretreatment of 0.02mg/kg cisatracurium. Conclusion The pretreatment of 0.02mg/kg cisatracurium given 5 minutes before succinylcholine injection could alleviate succinylcholine-induced fasciculations without influence on muscle relaxation effects and endotracheal intubating conditions, but did not affect the occurrence of myalgia at 24h postoperatively, and might produce transient diplopia and difficulty to open eyes. |
| keywords:Cisatracurium|Succinylcholine|Fasciculation|Myalgia |
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