| Fascin-1及CEA在非小细胞肺癌患者支气管肺泡灌洗液中的表达及意义 |
| 投稿时间：2016-01-01 修订日期：2016-01-01 点此下载全文 |
| 引用本文：李琪,肖贵华,常芬.Fascin-1及CEA在非小细胞肺癌患者支气管肺泡灌洗液中的表达及意义[J].医学研究杂志,2016,45(8):116-118 |
| DOI：
10.11969/j.issn.1673-548X.2016.08.031 |
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| 中文摘要:目的 探讨非小细胞肺癌患者支气管肺泡灌洗液（BALF）中Fascin-1检测的临床意义。方法 收集肺癌组60例及肺良性疾病组45例的BALF标本。采用双抗体夹心酶联免疫吸附试验（ELISA）方法检测BALF中的Fascin-1水平，采用放射免疫分析法检测BALF中的癌胚抗原（CEA）浓度。结果 肺癌组BALF中 Fascin-1及CEA水平均显著高于肺良性疾病组（P<0.01）。TNM分期中，有远处转移的肺癌Ⅳ期患者Fascin-1及CEA水平最高（P<0.05），分期越晚，CEA浓度越高（P<0.05）。50例肺癌患者经治疗后，BALF中Fascin-1及CEA水平较治疗前有明显下降（P<0.01）。BALF中 Fascin-1水平与肺癌病理类型无关（P>0.05）。BALF中Fascin-1与CEA水平呈正相关（r=0.713，P<0.01）。结论 检测BALF中Fascin-1对于及时发现肺癌远处转移、估计预后、判断疗效具有重要的意义。 |
| 中文关键词:肺肿瘤 Fascin-1 癌胚抗原 支气管肺泡灌洗液 |
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| Expression of Fascin-1 and CEA in Bronchoalveolar Lavage Fluid in Nonsmall-cell Lung Cancer and Its Clinical Significance |
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| Abstract:Objective To investigate clinical significance of detecting fascin-1 in bronchoalveolar lavage fluid(BALF) in nonsmall-cell lung cancer. Methods BALF samples of 60 lung cancer patients and 45 benign lung diseases patients were collected. Fascin-1 in BALF was detected by double antibody sandwich enzyme-linked immunosorbent assay(ELISA), and Carcinoembryonic antigen(CEA) in BALF was detected by radio immunoassay. Results Fascin-1 and CEA level in BALF in lung cancer group were both higher than benign lung diseases group(P<0.01). Fascin-1 and CEA level of stage Ⅳ patients with distant metastasis were the highest among the four stage(P<0.05). As staging was later, the concentration of CEA was higher(P<0.05). A significant reduction in fascin-1 and CEA level were found in BALF in 50 NSCLC patients after therapy including operation, radiotherapy or chemotherapy(P<0.01). Fascin-1 level in BALF did not relate with the pathological type of lung cancer. Fascin-1 level in BALF was linearly positively correlated with CEA(r=0.713, P<0.01). Conclusion Detection of fascin-1 in BALF is helpful to estimation of distal metastasis of cancer cells, evaluating prognosis and judging curative effect. |
| keywords:Lung neoplasms Fascin-1 Carcinoembryonic antigen Bronchoalveolar lavage fluid |
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