| 年龄校正D-二聚体在肺栓塞诊断的价值 |
| 投稿时间：2016-01-25 修订日期：2016-01-26 点此下载全文 |
| 引用本文：王升玲,孔英君.年龄校正D-二聚体在肺栓塞诊断的价值[J].医学研究杂志,2016,45(8):150-152 |
| DOI：
10.11969/j.issn.1673-548X.2016.08.039 |
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| 中文摘要:目的 研究随年龄校正的D-二聚体临界值在肺栓塞的诊断价值。方法 螺旋CT肺动脉造影作为诊断急性肺栓塞的金标准，采用酶联免疫吸附法检测疑似肺栓塞患者血浆D-二聚体浓度，分别计算随年龄校正的D-二聚体临界值组和传统临界值组的敏感度、特异性、准确性、阴性预测值和阳性预测值。结果 传统D-二聚体临界值组敏感度为93.75%，漏诊率为6.25%，特异性为50.36%，误诊率为49.64%，准确性为57.31%，阳性预测值26.50%，阴性预测值97.68%，Youden指数为0.44，年龄校正组相对应的分别是93.75%、6.25%、60.14%、39.86%、78.04%、30.99%、98.05%、0.54。结论 两组临界值的敏感度相同，但是年龄校正D-二聚体临界值的特异性、阴性预测值和准确性明显增加，两者之间Youden指数差异有统计学意义（P<0.01）。 |
| 中文关键词:肺栓塞 D-二聚体 年龄校正 |
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| Diagnostic Value of Age-adjusted D-dimer in Pulmonary Thromboembolism |
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| Abstract:Objective To study the diagnostic value of age-adjusted D-dimer combined with clinical probability in patients with pulmonary embolism. Methods Spiral CT pulmonary angiography for the diagnosis of acute pulmonary embolism is regarded as gold standard. The quantitative enzyme-linked immunosorbent assay (ELISA) was used to detect plasma D-dimer concentration in the suspected pulmonary embolism patients. Then we calculated separately sensitivity, specificity, accuracy, negative prediction value and positive predictive value of age-adjusted D-dimer cut-off groupand traditional cut-off group. Results The group of raditional D-dimer critical sensitivity was 93.75%, misdiagnosis rate was 6.25%, specificity of 50.36%.The rate of misdiagnosis was 49.64%, the accuracy was 57.31%, the positive predictive value was 26.5%, the negative predictive value was 97.68% and Youden index was 0.44. For another group, and the corresponding respectively was 93.75%,6.25%, 60.14%,39.86%,78.04%,30.99%, 98.5% and 0.54, respectively. Conclusion The sensitivity of the two groups was the same. But the specificity, negative predictive value and the accuracy of the age-adjusted D-dimer were significantly increased, and there were significant differences between the two groups, with P<0.01. |
| keywords:Pulmonary embolism D-dimer Age-adjusted |
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