| 右美托咪啶对急性A型主动脉夹层患者术后谵妄的影响 |
| 投稿时间：2016-03-19 修订日期：2016-04-04 点此下载全文 |
| 引用本文：程永庆,葛敏,周庆,陈涛,陈成,王东进.右美托咪啶对急性A型主动脉夹层患者术后谵妄的影响[J].医学研究杂志,2016,45(10):76-78,102 |
| DOI：
10.11969/j.issn.1673-548X.2016.10.019 |
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| 基金项目:江苏省科技专项基金资助项目（BL2014004） |
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| 中文摘要:目的 评价右美托咪啶对急性A型主动脉夹层患者术后谵妄的影响。方法 2014年2月~2015年10月于笔者所在科室行急性A型主动脉夹层手术患者28例，随机分为两组（n=14）：右美托咪啶组（A组）和生理盐水对照组（B组）。A组从脱机开始以0.8μg/（kg·h）的速率经静脉持续输注右美托咪啶至整个脱机过程，B组给予等容量生理盐水。记录两组术后谵妄发生情况、脱机指标（PaO2/FiO2、f/VT）、脱机持续时间和住ICU时间。结果 两组患者术后谵妄发生率相似（P>0.05）。与B组相比，A组患者发生谵妄的持续时间缩短，脱机指标改善，脱机持续时间和住ICU时间缩短（P<0.05）。结论 右美托咪啶可减轻急性A型主动脉夹层患者术后发生的谵妄，改善呼吸功能。 |
| 中文关键词:右美托咪啶 急性A型主动脉夹层 术后 谵妄 |
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| Impact of Deximeditomidine on Postoperative Delirium of Acute Type A Aortic Dissection Surgery |
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| Abstract:Objective To investigate the effect of dexmedetomidine on postoperative delirium of acute type A aortic dissection (AAD) surgery. Methods From February 2014 to October 2015, twenty eight patients undergone AAD surgery were randomly divided into 2 groups(n=14 each): dexmedetomidine group(group A) and saline control group(group B). Patients in group A received dexmedetomidine by continuous infusion at 0.8μg/(kg·h) at the beginning and throughout the weaning period from the mechanical ventilation whereas those in group B received saline at the equal volume. Postoperative delirium, weaning parameters(PaO2/FiO2、f/VT), weaning duration and intensive care unit(ICU) length of stay were recorded. Results The incidence of postoperative delirium was similar between the two groups(P>0.05). Compared with group B, delirium duration was shorter, weaning parameters were improved significantly, weaning duration and ICU length of stay were lower in patients developing delirium in group A(P<0.05). Conclusion Dexmedetomidine reduces the severity of postoperative delirium of acute type A aortic dissection and improves respiratory function. |
| keywords:Dexmedetomidine Acute type A aortic dissection Postoperative Delirium |
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