| SIRT-1和NF-κB在小细胞肺癌中的表达及其意义 |
| 投稿时间：2016-04-08 修订日期：2014-04-25 点此下载全文 |
| 引用本文：郭子君,齐晓丹.SIRT-1和NF-κB在小细胞肺癌中的表达及其意义[J].医学研究杂志,2016,45(11):152-157 |
| DOI：
10.11969/j.issn.1673-548X.2016.11.039 |
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| 中文摘要:目的 探讨沉默信息调节因子2相关酶-1（SIRT-1）、核因子-κB（NF-κB）在小细胞肺癌（SCLC）中的表达及其与临床特征的相关性，分析其与临床预后的关系。方法 采用SP法免疫组化检测79例局限期小细胞肺癌癌组织和69例癌旁正常肺组织中SIRT-1和P65的表达情况，结合临床资料进行相关性分析。采用电话形式进行随访，利用Kaplan-Meier曲线进行单因素生存分析，生存率比较采用Log-rank检验。结果 SCLC癌组织中，SIRT-1（χ2=38.581，P=0.000）和P65（χ2=26.348，P=0.000）的表达率均显著高于癌旁正常肺组织，与术前血清NSE水平呈正相关（χ2=6.707，P=0.010和χ2=4.017，P=0.045）。SCLC癌组织中，SIRT-1与P65的表达呈低度正相关（r=0.223，P=0.042）。SCLC中，SIRT-1表达阴性（χ2=15.117，P=0.000）、P65表达阴性（χ2=3.971，P=0.046）的患者，预后更好。结论 SIRT-1和NF-κB在SCLC患者的发生、发展过程中起到促进作用，并且可能与术后患者的预后相关。 |
| 中文关键词:小细胞肺癌 SIRT-1 NF-κB 预后分析 |
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| Expression and Significance of SIRT-1 and NF-κB in Small Cell Lung Cancer |
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| Abstract:Objective To investigate the expression and correlation of SIRT-1 and NF-κB in small cell lung cancer, and to analyze the relationship between the expression and clinical features and clinical prognosis. Methods SP immunohistochemistry was used to detect the expression of SIRT-1 and P65 in 79 selected cases of limited stage small cell lung cancer tissues and 69 cases of normal lung tissues, and to analyze the relationship between the expression and clinical prognosis, according to the clinical data. Follow up by telephone, and use the Kaplan-Meier curves to conduct univariate survival analysis, while survival rate was compared with Log-rank test. Results The expression of SIRT-1(χ2=38.581,P=0.000) and P65(χ2=26.348,P=0.000) were both significantly higher than those of normal lung tissues, and there was positive correlation between the expression of them and NSE level before surgery(χ2=6.707,P=0.010 and χ2=4.017,P=0.045). There was lowly positive correlation between the expression of SIRT-1 and P65(r=0.223,P=0.042). The patients with the low expression of SIRT-1(χ2=15.117,P=0.000) and P65(χ2=3.971,P=0.046) had a better prognosis. Conclusion SIRT-1 and P65 played a role in promoting the occurrence and development of SCLC patients, and might be related to the prognosis of patients after surgery. |
| keywords:Small cell lung cancer SIRT-1 NF-κB Risk factor |
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