| SETDB1在卵巢癌中的表达及临床意义 |
| 投稿时间：2016-03-02 修订日期：2016-03-11 点此下载全文 |
| 引用本文：董红玲.SETDB1在卵巢癌中的表达及临床意义[J].医学研究杂志,2017,46(3):145-148,152 |
| DOI：
10.11969/j.issn.1673-548X.2017.03.036 |
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| 中文摘要:目的 研究SET结构域分支型1（SET domain bifurcated 1，SETDB1）在人卵巢癌中的表达情况以及对患者预后的影响。方法 收集2010年1月~2012年12月间于笔者医院妇产科行手术切除的卵巢癌及对应癌旁组织共44例，运用qRT-PCR技术检测SETDB1 mRNA在卵巢癌及对应癌旁组织中的表达水平，免疫组化染色检测SETDB1蛋白的表达情况，通过卡方检验分析SETDB1蛋白表达与患者临床病理资料间的相关性，采用Kaplan-Meier生存曲线分析SETDB1蛋白表达水平对患者3年生存预后的影响。结果 卵巢癌组织中SETDB1显著高表达（P<0.05）；卵巢癌组织 SETDB1蛋白阳性表达与淋巴结转移（P<0.05）及较晚的FIGO分期（Ⅲ+Ⅳ，P<0.05）具有显著的相关性；与SETDB1蛋白表达阴性患者相比，SETDB1蛋白阳性表达的患者3年总生存率及无病生存率均显著降低（P<0.05）。结论 卵巢癌中SETDB1表达水平异常升高并与患者不良预后密切相关，SETDB1对卵巢癌患者可能具有一定的预后评价作用。 |
| 中文关键词:SETDB1 卵巢癌 表达 临床意义 |
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| Expression and Clinical Significance of SETDB1 in Human Ovarian Carcinoma |
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| Abstract:Objective To investigate the expression and clinical significance of SETDB1 in human ovarian carcinoma. Methods 44 ovarian carcinoma tissues and matched tumor-adjacent tissues were collected from January, 2010 to December, 2012. The mRNA expression of SETDB1 was detected by qRT-PCR, and the protein expression of SETDB1 was detected by immunohistochemistry. The correlation between SETDB1 and clinic pathological features was analyzed by chi-square test, and the Kaplan-Meier survival curves were drawn to describe the prognostic effects of SETDB1 expression. Results The expression of SETDB1 was up-regulated in ovarian carcinoma tissues compared to those matched tumor-adjacent tissues(P<0.05). Positive expression of SETDB1 was associated with lymphatic metastasis (P<0.05) and advanced FIGO stage (Ⅲ+Ⅳ, P<0.05). Both the 3-year overall survival rate and tumor-free survival rate were lower in SETDB1 positive expression group than SETDB1 negative expression group (P<0.05). Conclusion Positive expression of SETDB1 in human ovarian carcinoma is related to the poor prognosis. SETDB1 has a potential to predict the prognosis for ovarian carcinoma patients. |
| keywords:SETDB1 Ovarian carcinoma Expression Clinical significance |
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