| TGF-β1 509T/C基因多态性与肝硬化相关性的Meta分析 |
| 投稿时间：2017-04-20 修订日期：2017-04-29 点此下载全文 |
| 引用本文：于海滨,丁惠国.TGF-β1 509T/C基因多态性与肝硬化相关性的Meta分析[J].医学研究杂志,2017,46(7):36-40 |
| DOI：
10.11969/j.issn.1673-548X.2017.07.009 |
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| 基金项目:国家自然科学基金资助项目（31400761）；北京市自然科学基金资助项目（7142079） |
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| 中文摘要:目的 探索转化生长因子TGF-β1 509T/C基因多态性与肝硬化的关系。方法 计算机检索中国生物医学文献数据库、重庆维普中文科技期刊全文数据库、清华CNKI数据库、万方科技期刊全文数据库、PubMed，检索时间范围为建库到2017年3月。按纳入、排除标准选择TGF-β1 509位点基因多态性与肝硬化关系的病例对照研究。应用Stata 12.0软件对纳入的研究进行定量分析。结果 共纳入10个病例对照研究，Meta分析结果显示509位点携带T等位基因的肝炎肝硬化合并OR=1.07， 95% CI：0.81~1.41，显性基因模型分析（TT+CT vs CC） OR=1.08，95% CI：0.73~1.61，未发现显著发表偏倚。结论 未发现TGF-β1 509T/C基因多态性与肝硬化有显著性关系。 |
| 中文关键词:肝硬化 转化生长因子β1 基因多态性 遗传 Meta分析 |
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| Relationship between TGF-β1 509T/C Gene Polymorphism and Liver Cirrhosis:a Meta-Analysis |
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| Abstract:Objective To evaluate the relationship between genetic polymorphism of transforming growth factor(TGF) β1 and susceptibility of liver cirrhosis. Methods CBM,VIP, CNKI, Wanfang technological periodical full-text databases and Pubmed from set up to March, 2017 were electronically searched to identify case-control studies on the relationship between genetic polymorphism of TGF-β1 promoter 509 site, and liver cirrhosis. The data were quantitatively analyzed by Stata 12.0 software after assessing the quality of included studies. Results Ten case-control studies were selected for Meta-analysis based on our inclusion and exclusion standards. The results of Meta-analysis showed that the pooled OR value for liver cirrhosis with T allele of TGF-β1 gene at promoter 509 was 1.07 (95%CI:0.81-1.41), the pooled OR values of dominant gene model analysis (TT + CT vs CC) were 1.08 (95%CI:0.73-1.61). No significant publication bias was found. Conlcusion The genetic polymorphism of TGF-β1 at promoter 509 showed no association with susceptibility of liver cirrhosis. |
| keywords:Liver cirrhosis Transforming growth factor beta1 Genetic polymorphism Enetic Meta-analysis |
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