| CTP在STA-MCA治疗烟雾病中的应用 |
| 投稿时间：2016-10-26 修订日期：2016-11-11 点此下载全文 |
| 引用本文：杨升,黄书岚.CTP在STA-MCA治疗烟雾病中的应用[J].医学研究杂志,2017,46(7):148-152 |
| DOI：
10.11969/j.issn.1673-548X.2017.07.037 |
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| 中文摘要:目的 探讨CT灌注成像（CTP）在烟雾病（MMD）行颞浅动脉-大脑中动脉搭桥（STA-MCA）中的应用价值。方法 回顾性分析21例全脑血管造影确诊为烟雾病，并行血管重建的病例资料。所有纳入患者均于术前、术后行头颅CTP检查，然后对图像进行后处理，划定特定区域作为感兴趣区（ROI），取得脑血流量（CBF）、脑血容量（CBV）、平均通过时间（MTT）、达峰时间（TTP）的参数值。计算术侧/对侧相对比值（rCBF、rCBV、rMTT、rTTP），采用t检验比较手术前后CTP参数及相对值的差异。结果 21例患者术后行DSA检查示搭桥血管血流通畅，所有患者术后CBF增加，80.95%的患者 CBV增加，90.48%的患者MMT缩短，85.71%的患者 TTP缩短；100%的患者rCBF增加，71.43%的患者rCBV增加，100% 的患者rMMT减小，57.14%的患者 rTTP减小。CBF、CBV、MTT、rCBF、rMTT等参数在术前、术后的比较差异具有统计学意义（P<0.05）。结论 CTP可对烟雾病STA-MAC手术前后的血流动力学变化情况进行比较，判断手术指征，评估手术效果。 |
| 中文关键词:CT灌注 烟雾病 颞浅动脉-大脑中动脉搭桥 感兴趣区 |
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| Application of CTP in STA-MAC Treat Moyamoya Disease |
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| Abstract:Objective To investigate the application of Computed tomography perfusion imaging (CTP) in superficial temporal artery-middle cerebral artery bypass(STA-MAC) treated moyamoya disease (MMD). Methods The clinical data of 21 patients with MMD who received STA-MAC surgery were collected.CTP was performed before and after the surgery for all the patients included.We routinely delimited the corresponding position as regions of interest (ROI) and obtained value of the cerebral blood flow(CBF), cerebral blood volume(CBV), the mean transittime(MTT), time to peak(TTP).The deviations of rCBF,rCBV,rMTT,rTTP between the affected side and corresponding area were analysed and the paired t test was performed. Results Unobstructed blood flow was observed in all patients received STA-MAC surgery after DSA examination.Increased CBF was observed in 100% patients and increased CBV in 80.95% patients,shortened MMT in 80.95% patients,shortened TTP in 85.71% patients. Difference of CBF, CBV, MTT,r-CBF,rMTT between pre-and post-Operation had statistical significance (P<0.05). Conclusion CTP is important in elucidating the hemodynamic changes before and after STA-MCA bypass,which indicts a crucial role in evaluating therapeutic effect of surgical treatment for MMD. |
| keywords:CT perfusion Moyamoya disease Superficial temporal artery-middle cerebral artery bypass Region of interest |
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