| 右美托咪定预防全身麻醉后导尿患者阴茎勃起和苏醒期膀胱刺激征 |
| 投稿时间：2016-11-26 修订日期：2016-12-12 点此下载全文 |
| 引用本文：孙成成,楼群兵,李军.右美托咪定预防全身麻醉后导尿患者阴茎勃起和苏醒期膀胱刺激征[J].医学研究杂志,2017,46(8):157-159,163 |
| DOI：
10.11969/j.issn.1673-548X.2017.08.039 |
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| 中文摘要:目的 观察右美托咪定对全身麻醉诱导后导尿患者阴茎勃起和苏醒期膀胱刺激征的预防作用。方法 拟行择期外科手术男性患者1000例，ASA分级Ⅰ~Ⅱ级，随机分为C、D两组（n=500）。C组为对照组，D组为右美托咪定组。C组和D组在麻醉诱导前15min分别静脉泵注生理盐水和右美托咪定1μg/kg，均在完成麻醉诱导并气管插管后10min内开始导尿，观察两组患者给药前（T0）、全麻诱导前（T1）、气管插管后导尿前（T2）、导尿过程中（T3）阴茎勃起的发生率及程度，记录两组患者苏醒期膀胱刺激征的发生率及程度。结果 C组在T3时间点高发并分级最高（与T2点相比，P<0.05），D组两时间点发生例数及分级差异无统计学意义（P>0.05）。D组在T2和T3时间点阴茎勃起发生率分别为4.0%和5.6%，明显低于C组（15.4%、77.8%，P<0.05）；在T3时间点阴茎勃起1级、2级和3级发生率分别为4.4%、1.0%和0.2%，明显低于C组（62.6%、11.4%、3.8%，P<0.05）。D组苏醒期膀胱刺激征发生率明显低于C组（28.4% vs 63.0%，P<0.05），其中1分、2分及3分的发生率分别为15.6%、10.4%及2.4%，明显低于C组（22.0%、21.0%、20.0%，P<0.05）。结论 1μg/kg右美托咪定全身麻醉诱导前泵注可预防导尿过程中阴茎勃起和苏醒期膀胱刺激征的发生，提高患者的舒适度。 |
| 中文关键词:右美托咪定 阴茎勃起 膀胱刺激征 |
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| Dexmedetomidine Prevent Penile Erection after General Anesthesia Induction and Bladder Irritation during Recovery |
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| Abstract:Objective To observe the preventive effect of dexmedetomidine on penile erection(PE) after general anesthesia induction and urinary bladder irritation during recovery(UBIR) with urethral catheterization in male patients. Methods A total of 1000 male patients with ASA grade Ⅰ~Ⅱ were randomly divided into control group(group C) and dexmedetomidine group (group D,n=500). Dexmedetomidine (1μg/kg) was intravenous pumped in group D and saline was given in group C 15 minutes before anesthesia induction. Both groups started catheterization within 10 minutes after endotracheal intubation. The incidence and grade of PE before infusion(T0),before induction(T1), before catheterization(T2) and during catheterization (T3) were observed. The degree and extent of UBIR were observed and recorded. Results The incidence and grade of PE at T3 time-point in group C were highest (Compared with T2 and other time-points, P<0.05), but there was no statistically differences in incidence and grade of PE in group D between at T3 and T2 time-points (P>0.05). The incidence of PE at T2 and T3 time-points were 4.0% and 5.6% in group D, which was significantly lower than those in group C (15.4%, 77.8%, P<0.05). The incidence of PE at grade 1, 2 and 3 was 4.4%, 1.0% and 0.2% respectively in group D, which was significantly lower than those in group C (62.6%, 11.4%, 3.8%, P<0.05). The incidence of UBIR was significantly lower (28.4% vs 63.0%, P<0.05), among which the incidence of UBIR at grade 1, 2 and 3 were 15.6%, 10.4% and 2.4%,which was significantly lower in group D than those in group C (22.0%, 21.0%, 20.0%, P<0.05). Conclusion 1μg/kg dexmedetomidine pumped before anesthesia induction could prevent the occurrence of PE during catheterization and UBIR, which can improve patients' comfort. |
| keywords:Dexmedetomidine Penile erection Bladder irritation |
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