| 单独与联合介入治疗肝癌的临床对比分析 |
| 投稿时间：2016-12-16 修订日期：2016-12-26 点此下载全文 |
| 引用本文：吴洋洋,王爱平,董岚,孙亚臣,王瑶,王海莉,郝锐.单独与联合介入治疗肝癌的临床对比分析[J].医学研究杂志,2017,46(9):80-83 |
| DOI：
10.11969/j.issn.1673-548X.2017.09.022 |
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| 基金项目:吉林省吉林市科学技术局民生科技创新专项基金资助项目（2015334007） |
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| 中文摘要:目的 分析比较射频消融术（RFA）联合肝动脉化疗栓塞术（TACE）与单独TACE治疗肝癌的临床疗效。方法 回顾性分析2009年6月~2015年12月因肝癌到北华大学附属医院住院的患者58例，RFA+TACE 25例（为实验组），单独TACE 33例（为对照组）。统计学方法对比分析两组治疗前、治疗后1周及1个月的肝功能、中性粒细胞/淋巴细胞比值（NLR）、甲胎蛋白（AFP）、异常凝血酶原（PIVKA-Ⅱ）、CT/MRI，并随访1年。结果 1两种治疗方法未明显加重肝脏的损伤；2两组NLR较治疗前均降低，实验组较对照组降低更明显，组间比较差异有统计学意义（P<0.05）；3实验组与对照组PIVKA-Ⅱ较治疗前减低，实验组降低更明显，组间及组内比较差异有统计学意义（P<0.05）；4AFP较治疗前均降低，差异具有统计学意义（P<0.05），组间比较P=0.512，差异无统计学意义；5实验组与对照组有效率分别为88.0%、63.6%，差异有统计学意义（P=0.036）；61年生存率分别为76.0%（19/25）、72.7%（24/33），差异无统计学意义（P>0.05）。结论 联合治疗并未明显加重肝脏的损伤，能更好地维持促肿瘤炎性状态与抗肿瘤免疫状态的平衡性，比单独治疗肝癌的疗效更好，值得临床推广。 |
| 中文关键词:肝癌 射频消融术 肝动脉化疗栓塞术 |
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| Comparative Analysis of the Simple Intervenient and the Combined Intervenient Therapies for the Hepatocellular Carcinoma |
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| Abstract:Objective To explore the clinical efficacy of the radiofrequency ablation combined with transcatheter arterial chemoembolization and the transcatheter arterial chemoembolization for the hepatocellular carcinoma. Methods In this retrospective study,58 cases of the hepatocellular carcinoma patients in Beihua University from June 1,2009 to December 1,2015 were included into survey. 25 patients with the RFA+TACE were selected as experimental group, and 33 cases with the TACE were selected as control group. We detected and analysis the liver function,NRL,AFP,PIVKA-Ⅱ,CT/MRI before and after one week or month of the therapy.All the patients were followed up for 1 year. Results (1)The two methods did not increase the damage of liver.(2)the NLR of the two gropes was decreased.The experimental group was more obvious and the difference was statistically significant(P<0.05).(3)The decline about PIVKA-Ⅱ of the experimental group was more obvious than the control group,and the difference was statistically significant(P<0.05).(4)The AFP levels of the two groups were decreased,and the difference had statistically significant(P<0.05);but the comparison among the two groups had no statistically significant(P>0.05).(5)The remission rate of the two groups was 88.0%,63.6%,and the difference was statistically significant(P<0.05).(6)But the survival rates of the experimental and control groups respectively were 76.0%(19/25).72.7%(24/33), and the difference has no statistically significant (P>0.05). Conclusion The combined intervenient therapies can keep a better balance between relieving immune suppression and switching the inflammatory state,and will not obviously accentuated the liver damage.The combined treatment can improve therapeutic efficacy,and is worthy of clinical promotion. |
| keywords:Hepatocellular carcinoma Radiofrequency ablation Transcatheter arterial chemoembolization |
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