| 结直肠癌组织中MST3的表达和临床意义 |
| 投稿时间：2017-09-21 修订日期：2017-09-30 点此下载全文 |
| 引用本文：孙昭,高鹤丽,周娜,白春梅,韩钦.结直肠癌组织中MST3的表达和临床意义[J].医学研究杂志,2018,47(5):32-35 |
| DOI：
10.11969/j.issn.1673-548X.2018.05.008 |
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| 基金项目:国家自然科学基金资助项目（81472785、81672313） |
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| 中文摘要:目的 检测MST3在结直肠癌（colorectal cancer，CRC）组织的表达，评价其对CRC预后的影响。方法 免疫组化检测MST3在CRC肿瘤组织及瘤旁正常组织中的表达，分析MST3和临床病理因素之间的关系以及MST3表达对CRC患者无病生存期（disease free survival，DFS）的影响。结果 75例CRC患者中，肿瘤组织MST3表达阴性的为39例，阳性的36例，而癌旁组织中MST3阳性的为52例，阴性的为23例，MST3表达在肿瘤组织中显著低于癌旁组织（P=0.030）。肿瘤组织中MST3阳性的患者DFS为74.9±7.4个月（95%CI：60.5~87.3个月），阴性患者DFS为43.2±5.3个月（95%CI：32.9~53.5个月）比较差异有统计学意义（P=0.043）。结论 MST3在结直肠癌肿瘤组织表达低于癌旁组织，CRC患者肿瘤组织MST3阳性的DFS更长。 |
| 中文关键词:MST3 结直肠癌 预后 |
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| MST3 Expression in Colorectal Carcinoma and Its Clinical Significance |
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| Abstract:Objective To detect the MST3 expression in colorectal carcinoma (CRC) and to evaluate its effect on the prognosis of CRC.Methods Expression of MST3 in CRC tumor tissues and adjacent normal tissues was detected by immunohistochemistry. The association between MST3 expression and clinicpathological parameters and prognosis was subsequently determined.Results Of 75 CRC patients, MST3 expression of cancer tissue was positive in 36 patients, negative in 39 patients, MST3 expression of pericarcinous tissue was positive in 52 patients and negative in 23 patients. MST3 expression rate was significantly lower in CRC cancer tissue than in pericarcinous tissue(P=0.030). The DFS of MST3-postive colorectal cancer patients was 74.9±7.4m(95% CI:60.5-87.3months),which was significantly longer than that of MST3-negative patients[DFS is 43.2±5.3months(95% CI:32.9-53.5months)], P=0.043.Conclusion MST3 expression decreases in colorectal cancer tissue, and a positive MST3 expression predicts a better prognosis in CRC patients. |
| keywords:MST3 Colorectal carcinoma Prognosis |
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