| 慢性前列腺炎与根治性前列腺切除术后生化复发的相关性研究 |
| 投稿时间：2017-10-31 修订日期：2017-11-10 点此下载全文 |
| 引用本文：曹彬,陈平,徐胜利,肖和,徐德强,张新华.慢性前列腺炎与根治性前列腺切除术后生化复发的相关性研究[J].医学研究杂志,2018,47(8):24-28 |
| DOI：
10.11969/j.issn.1673-548X.2018.08.007 |
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| 基金项目:国家自然科学基金资助项目（210700145） |
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| 中文摘要:目的 探讨慢性前列腺炎与根治性前列腺切除术后生化复发的相关性。方法 回顾性分析笔者医院自2010年6月~2016年6月期间所有行腹腔镜根治性前列腺切除术患者的临床资料，根据穿刺病检结果分为慢性前列腺炎组（CP）及非慢性前列腺炎组（NCP），比较两组患者临床、病理特点、无生化复发率及无无生化复发生存期的差异。结果 中位随访50个月。171例患者中，50例出现生化复发，其中CP组18例（36.00%），NCP组22例（18.19%），生化复发时间为11~72个月，平均49个月。CP组术前PSA、术前Gleason评分及术后Gleason评分均高于NCP组（P<0.05）。单因素、多因素Cox回归分析示慢性前列腺炎是生化复发的高危因素（HR=2.262，95%CI：1.180~4.336）。Kaplan-Meier分析示CP组无生化复发率及无生化复发生存期明显低于NCP组（P<0.05）。结论 慢性前列腺炎是根治性前列腺切除术后生化复发的高危因素，慢性前列腺炎可能促进了前列腺癌的发生、发展。 |
| 中文关键词:前列腺癌 生化复发 慢性前列腺炎 根治性前列腺切除术 |
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| Association between Chronic Prostatitis and Biochemical Recurrence after Radical Prostatectomy |
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| Abstract:Objective To explore the association between chronic prostatitis and biochemical recurrence after radical prostatectomy. Methods The clinical data of all patients with prostate cancer who treated with laparoscopic radical prostatectomy from June 2010 to June 2016 were analyzed retrospectively. These patients were divided into chronic prostatitis group (CP) and non chronic prostatitis group (NCP), according to the result of the biopsy.Clinical and pathologic variables, biochemical recurrence-free survival rate and biochemical recurrence-free survival time were compared between the two groups. Results At a median follow-up of 50 months.171 patients met the inclusion criteria, 50 had biochemical recurrence, of which 18 (36%) in CP group and 22 (18.19%) in NCP group, the biochemical recurrence-free survival time was 11-72months, 49months on average.Patients in CP group had significantly higher preoperative PSA, preoperative and postoperative Gleason score compared to NCP group. On the univariate analysis and multivariate Cox analysis found that chronic prostatitis was significantly associated with biochemical recurrence (HR=2.262, 95%CI:1.180-4.336). Kaplan-Meier analysis found that patients in CP group had significantly lower biochemical recurrence-free survival rate and biochemical recurrence-free survival time compared to NCP group. Conclusion Chronic prostatitis is a high risk factor for biochemical recurrence after radical prostatectomy, may promote the development and progression of prostate cancer. |
| keywords:Prostate cancer Biochemical recurrence Chronic prostatitis Radical prostatectomy |
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