| 超声造影对急性脑梗死患者不稳定斑块的应用研究 |
| 投稿时间：2017-12-06 修订日期：2017-12-21 点此下载全文 |
| 引用本文：姚俊东,张周龙,王运昌.超声造影对急性脑梗死患者不稳定斑块的应用研究[J].医学研究杂志,2018,47(10):100-103 |
| DOI：
10.11969/j.issn.1673-548X.2018.10.027 |
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| 基金项目:洛阳市科技计划医疗卫生项目（1603001A-10） |
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| 中文摘要:目的 分析超声造影技术（contrast-enhanced ultrasound，CEUS）对急性脑梗死患者（acute cerebral infarction，ACI）不稳定斑块（unstable plaque，UP）的评估与发病风险预测。方法 将所纳入的急性脑梗死患者（有症状组，n=53）和无心脑血管病患者（无症状组，n=42）依次进行常规颈动脉超声及超声造影检查，测量并对比分析不稳定性斑块的大小、增强强度（EI）及增强比率（Ratio）。结果 有症状组的增强强度（EI）大于无症状组，差异有统计学意义（t=2.895，P=0.005）；有症状组的增强比率（Ratio）高于无症状组，差异有统计学意义（t=3.202，P=0.002）；有症状组与无症状组斑块的长度、厚度两组比较结果均显示差异无统计学意义（P>0.05）。绘制的ROC曲线所知，当EI截点值为3.785dB时，预测急性脑梗死发生的敏感度为49.06%、特异性为80.95%；Ratio截点值为0.215，此时的敏感度为58.49%、特异性为71.43%。结论 超声造影技术可以对不稳定性斑块进行量化分析，斑块的增强强度、增强比率越高其稳定性越低，并对预测ACI的发病风险提供更加客观的依据。 |
| 中文关键词:超声造影 急性脑梗死 不稳定斑块 增强强度 增强比率 |
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| Application Study of Contrast-enhanced Ultrasound in the Unstable Plaques of Cerebral Ischemic Stroke |
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| Abstract:Objective To analyze the evaluation and risk prediction of unsteady plaques (up) in patients with acute cerebral infarction (ACI) by contrast-enhanced Ultrasound (CEUS). Methods 95 patients have been screened out and were divided into two groups-the symptomatic group (n=53) and asymptomatic group (n=42).We inspected them by means of conventional ultrasound and contrast enhanced ultrasound in order to measure and contrast the size, enhanced intensity (EI) and enhancement Ratio of UP. Results The enhancement intensity (EI) of the symptom group was higher than the asymptomatic group, and here comes a significant difference(t=2.895,P=0.005). The enhancement Ratio of the symptom group was higher than the asymptomatic group, and here comes a significant difference(t=3.202,P=0.002).There were no significant difference in the length and thickness of UP between the two groups (P>0.05). According to the ROC curve was drawn, the sensitivity and specificity of EI(AUC=0.663, cut-off value=3.785dB) in predicting cerebral ischemic stroke was 49.06% and 80.95%respectively, and the sensitivity and specificity of ratio(AUC=0.677, cut-off value=0.215) in predicting cerebral ischemic stroke was 58.49% and 71.43%respectively. Conclusion The texture of unstable plaque can be analysed quantitatively by using contrast-enhanced ultrasound. EI and ratio of unstable plaque is one of a positive correlation with vulnerability, and provide more objective basis for predicting the onset of acute ischemic stroke risk. |
| keywords:Ultrasonography Cerebral ischemic stroke Unstable plaques Enhanced intensity Ratio |
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