| 血清小而密低密度脂蛋白胆固醇与脂肪肝相关性分析 |
| 投稿时间：2018-03-12 修订日期：2018-03-28 点此下载全文 |
| 引用本文：梁国威,李秀锋,徐旭,邵冬华.血清小而密低密度脂蛋白胆固醇与脂肪肝相关性分析[J].医学研究杂志,2018,47(12):166-168 |
| DOI：
10.11969/j.issn.1673-548X.2018.12.038 |
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| 中文摘要:目的 探讨血清小而密低密度脂蛋白胆固醇（sdLDL-C）在脂肪肝患者中变化情况及其与脂肪肝的相关性。方法 收集来笔者医院健康体检人群1012例，根据B型超声检测结果分为脂肪肝组442例（男性/女性：309/133）和非脂肪肝组570例（男性/女性：311/259）。血清sdLDL-C检测采用过氧化物酶法。结果 脂肪肝组sdLDL-C水平显著高于非脂肪肝组（1.09±0.44mmol/L vs 0.77±0.35mmol/L，P=0.000）。多元线性回归分析显示，sdLDL-C与总胆固醇（TC）、甘油三酯（TG）和丙氨酸氨基转移酶（ALT）呈正相关（P=0.000），与高密度脂蛋白胆固醇（HDL-C）呈负相关（P=0.000）。Logistic回归分析显示，控制基础指标和肝功能指标ALT后，sdLDL-C与脂肪肝具有独立的相关性（P=0.000），但增加血脂指标TC、TG和HDL-C变量后，sdLDL-C不再与脂肪肝具有独立相关性（P=0.349）。结论 脂肪肝患者sdLDL-C显著增高，sdLDL-C不是脂肪肝患病的独立危险因素，降脂治疗是降低血循环中sdLDL-C水平的主要靶点。 |
| 中文关键词:小而密低密度脂蛋白胆固醇 脂肪肝 相关性 |
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| Association between Serum Small, Dense Low-density Lipoprotein Cholesterol and Fatty Liver |
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| Abstract:Objective To investigate the changes of serum small, dense low-density lipoprotein cholesterol (sdLDL-C) in patients with fatty liver and its correlation with fatty liver. Methods Totally 1012 subjects were enrolled in an annual health check-up program, and who were divided into 442 cases (men 309 and women 133) with fatty liver and 570 cases (men 311 and women 259) with no-fatty liver as controls according to ultrasonography. Serum sdLDL-C concentrations were measured by peroxidase assay. Results The level of sdLDL-C in fatty liver patients was significantly higher than that in non-fatty liver subjects (1.09±0.44mmol/L vs 0.77±0.35mmol/L, P=0.000). Multiple linear regression analysis showed that sdLDL-C was strong independent positive correlation with total cholesterol (TC), triglyceride (TG) and alanine aminotransferase (ALT) (all P=0.000), and strong independent negative correlation with high density lipoprotein cholesterol (HDL-C) (P=0.000). Logistic regression analysis showed that sdLDL-C was independently associated with fatty liver (P=0.000) after adjusted for Basic detection index and liver function index of ALT, However, sdLDL-C no longer had an independent association with fatty liver (P=0.349) after increasing TC, TG and HDL-C as dependent variables. Conclusion Serum sdLDL-C levels were significantly higher in patients with fatty liver. sdLDL-C was not an independent risk factor for fatty liver disease. Lipid-lowering therapy was the main target of reducing serum sdLDL-C level. |
| keywords:Small, Dense low-density lipoprotein cholesterol Fatty liver Association |
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