| 免疫细胞与心力衰竭的孟德尔随机化研究 |
| 投稿时间：2024-07-09 修订日期：2024-08-19 点此下载全文 |
| 引用本文：张艺博,卢健棋,毛美玲,董礼,杨尚冰,肖湘.免疫细胞与心力衰竭的孟德尔随机化研究[J].医学研究杂志,2025,54(1):25-30, 42 |
| DOI：
10.11969/j.issn.1673-548X.2025.01.006 |
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| 基金项目:国家自然科学基金地区基金资助项目(82160887)；国家中医临床研究基地业务建设第二批科研专项课题(JDZX2015146)；国家中医药传承创新中心项目(2023019-10)；广西自然科学基金资助项目(2021GXNSFBA196018)；广西岐黄学者培养项目(2022015-003-02)；广西自然科学基金资助项目(面上项目)(2021GXNSFAA220111)；广西中医药管理局自筹经费科研课题(GXZYA20230065) |
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| 中文摘要:目的 采用全面的两样本孟德尔随机化分析,以确定免疫细胞与心力衰竭之间的因果关系。方法 免疫细胞数据来自全基因组关联分析汇总统计数据。心力衰竭的数据来自FinnGens数据库。采用逆方差加权法、MR-Egger回归法、加权中位数法和加权模型法来研究免疫细胞与心力衰竭之间的因果关系。采用综合敏感度分析验证结果的稳健性、异质性和水平多效性。通过Stsiger检测,判断心力衰竭与免疫细胞之间有无反向因果关系。结果 731个免疫细胞共获得了2557个SNP,在调整之前,共有25个免疫表型被确定为具有因果作用。经过Bonferroni调整后,只有3个结果保留了统计显著性。逆方差加权法法分析表明,其中淋巴细胞绝对数与心力衰竭风险提高存在显著因果关系(OR=1.199,95% CI:1.104～1.302,P=1.70×10-5)；T细胞绝对数(OR=1.186,95% CI:1.095～1.284,P=2.84×10-5)；浆细胞样树突状细胞绝对数(OR=1.137,95% CI:1.056～1.224,P=0.0007)与心力衰竭呈正相关。通过Stsiger检测,判断心力衰竭与免疫细胞之间无反向因果关系。结论 免疫细胞与心力衰竭发生风险存在因果关系。 |
| 中文关键词:免疫细胞 心力衰竭 孟德尔随机化 因果关系 |
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| Mendelian Randomization Study on Immune Cells and Heart Failure. |
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| Abstract:Objective To utilize a comprehensive two-sample Mendelian randomized analysis for determining the causal relationship between immune cells and heart failure. Methods Immune cell data were collected from the genome-wide association analysis database, while the data of heart failure were obtained from the FinnGen database. The inverse variance weighted method, MR-Egger regression method, weighted median method, and weighted model method were employed to analyze the causal relationship between immune cells and heart failure. Comprehensive sensitivity analysis was utilized to verify the robustness, heterogeneity, and level pleiotropy of the results. The Stsiger test was applied to determine whether there was a reverse causal relationship between heart failure and immune cells. Results A total of 2557single nucleotide polymorphisms (SNP) were obtained from 731 immune cells. A total of 25 immunophenotypes were identified as having a causal function before the adjustment. After Bonferroni adjustment, only three results retained statistical significance. The inverse variance weighted analysis showed that there was a significant causal relationship between the absolute lymphocyte count and the increased risk of heart failure (HF) (OR=1.199,95% CI:1.104-1.302, P=1.70×10-5). The absolute count of T cells (OR=1.186,95% CI:1.095-1.284, P=2.84×10-5), and the absolute count of plasma-like dendritic cells (OR=1.137,95% CI:1.056-1.224, P=0.0007) were positively correlated with HF. The Stsiger test did not detect a causal relationship between heart failure and immune cells. Conclusion There exists a causal relationship between immune cells and the risk of heart failure. |
| keywords:Immune cells Heart failure Mendelian randomization Causal relationship |
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