| 基于数据挖掘分析儿童上气道咳嗽综合征中医辨治规律 |
| 投稿时间：2024-07-29 修订日期：2024-08-08 点此下载全文 |
| 引用本文：顾思睿,赵敬军,刘小琪,董子琪,申明君,王君.基于数据挖掘分析儿童上气道咳嗽综合征中医辨治规律[J].医学研究杂志,2025,54(2):35-42, 109 |
| DOI：
10.11969/j.issn.1673-548X.2025.02.007 |
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| 基金项目:国家重点研发计划项目(2018YFC1704100,2018YFC1704105)；国家自然科学基金青年科学基金资助项目(81704163) |
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| 中文摘要:目的 探讨儿童上气道咳嗽综合征的证候特征及中医处方用药规律。方法 检索中国知网学术期刊数据库、维普全文数据库、万方数据知识服务平台及中国生物医学文献服务系统自建库以来至2023年12月1日的中药治疗上气道咳嗽综合征的文献,提取其证候、症状及方剂配伍,利用中医传承计算平台V3.5进行数据挖掘。结果 最终纳入文献93篇,25种证型,119首方剂,中药199味,咳嗽以晨起咳嗽为主,高频症状为鼻塞、流涕、咽后壁可见黏液附着等,25.29%的患儿伴随鼻后滴漏感；证型以“风热犯肺证”为主,其次为“痰热郁肺证”“风痰恋肺证”等,中药使用频次前5位为辛夷、桔梗、苍耳子、甘草、白芷；药性以温、寒为主,五味以辛、苦为多；归经多为肺经,核心药对为“辛夷、苍耳子”“辛夷、桔梗”“桔梗、甘草”。通过K-Means聚类得到3对核心药物组合,均为苍耳子汤加减,其治疗以宣肺、通窍为主。结论 儿童上气道咳嗽综合征诊治需重视鼻咽部体征,在疏风清热、宣肺止咳的同时需重视通窍利咽,以达肺鼻同治,肺喉同治之效。 |
| 中文关键词:上气道咳嗽综合征 儿童 证候特征 用药规律 |
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| Analysis of the Traditional Chinese Medical Treatment Rules of Children with Upper Airway Cough Syndrome Based on Data Mining. |
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| Abstract:Objective To investigate the syndromic characteristics of upper airway cough syndrome in children and the rules of traditional Chinese medicine (TCM) prescription and medication. Methods The literature related to the treatment of upper airway cough syndrome in children by TCM in CNKI, Weipu, Wanfang and China Biomedical Literature Service System from the establishment of the database to December 1,2023 was retrieved, extracted the symptoms, signs and prescriptions, and performed data mining using the Chinese Medicine Inheritance Computing Platform V3.5. Results Ninety-three articles, 25 types of symptoms, 119 prescription and 199 flavors of TCM were finally included in the study. The cough was mainly in the morning, and the high-frequency symptoms were nasal congestion, runny nose, and mucus adherence on the posterior wall of the pharynx, and the postnasal drip sensation was present in 25.29% of the children; The main type of symptoms was "wind-heat offending the lungs", followed by "phlegm-heat depleting the lungs" and "wind-phlegm adhering to the lungs", etc. The top five TCM used were Flos magnoliae, Balloonflower root, Siberian cocklebur fruit, Liquorice root and Angelica dahurica; the medicinal properties of these medicines were mainly warm-natured and cold-natured, and the five flavors of these medicines were mainly pungent and bitter; most of the categorized meridians were the lung meridian, and the core medicinal pairs were "Flos magnoliae, Siberian cocklebur fruit" "Flos magnoliae, Balloonflower root", "Balloonflower root, Liquorice root". Three pairs of core drug combinations were obtained by K-Means clustering, all of which were additions to Siberian cocklebur fruit decoction, and their treatment was based on ventilate the lung and inducing resuscitation. Conclusion The diagnosis and treatment of upper airway cough syndrome in children should pay attention to the nasopharyngeal signs, and should pay attention to the passage of the orifices and the pharynx while dredging the wind and clearing the heat and promoting the lung to stop coughing, so as to achieve the effect of the simultaneous treatment of the lung and nose and the lung and throat. |
| keywords:Upper airway cough syndrome Children Syndromic characteristics Medication rule |
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